Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | KDM6B | O15054 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2585707 | 0.93 | RAB9A (0.54) | EPHX2NPC1RAB9AFAAHALDH1A1 | |
| SCHEMBL2585532 | 0.85 | HIF1A (0.52) | TSHRNPC1RAB9AALDH1A1HPGD | |
| SCHEMBL2576273 | 0.82 | ALDH1A1 (0.48) | TSHRNPC1RAB9AALDH1A1HPGD | |
| SCHEMBL2582407 | 0.80 | P2RX7 (0.54) | ROCK2HIF1A | |
| SCHEMBL2585139 | 0.79 | LMNA (0.58) | TSHRALDH1A1HPGDHTTPOLB | |
| SCHEMBL1475037 | 0.78 | HIF1A (0.62) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL2581683 | 0.78 | ECE1 (0.48) | RAB9AROCK2KMT2ASMN1; SMN2HIF1A | |
| SCHEMBL2585927 | 0.77 | WNT1 (0.46) | ALDH1A1HTTHSD17B10SMN1; SMN2KDM4E | |
| SCHEMBL2586922 | 0.76 | HIF1A (0.72) | NPC1RAB9AALDH1A1HTTNPSR1 | |
| SCHEMBL2581684 | 0.76 | PIN1 (0.46) | NPC1RAB9AMAPTL3MBTL1KDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |