SCHEMBL2597834

SCHEMBL2597834

COC(=O)C(Cc1c[nH]cn1)NC(=O)CCN

nearest known ligand 0.48

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 10/20 0.48
HDAC1 Q13547 8/20 0.48
MEN1 O00255 1/20 0.42
HCRTR1 O43613 1/20 0.42
KMT2A Q03164 1/20 0.42
TPSAB1 Q15661 1/20 0.39
PARP1 P09874 1/20 0.39
PARP3 Q9Y6F1 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19451083 1.00 HDAC6 (0.48) HDAC6HDAC1MEN1HCRTR1KMT2A
Hydrochloric Acid SCHEMBL2597395 0.99 HDAC6 (0.47) HDAC6HDAC1MEN1HCRTR1KMT2A
SCHEMBL6130220 0.90 HDAC6 (0.39) HDAC6HDAC1KMT2A
Hydrochloric Acid SCHEMBL3794525 0.89 HDAC6 (0.41) HDAC6HDAC1MEN1HCRTR1KMT2A
SCHEMBL6942067 0.88 MAPT (0.43) HDAC6HDAC1MEN1HCRTR1KMT2A
SCHEMBL6130186 0.86 ITGB3 (0.41) HDAC6HDAC1MEN1HCRTR1KMT2A
Carnosine SCHEMBL3904964 0.86 ITGB3 (0.41)
Carnosine SCHEMBL1161010 0.86 ITGB3 (0.41)
Carnosine SCHEMBL33769 0.86 ITGB3 (0.41)
Carnosine SCHEMBL33768 0.86 ITGB3 (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2035444-B1 DIPEPTIDE COMPOUNDS CONTAINING D-HISTIDINE FLAMMA SPA (IT) 2015-09-02 EP claimed
US-20090306165-A1 DIPEPTIDE COMPOUNDS CONTAINING D-HISTIDINE FLAMMA S.P.A. (IT) 2009-12-10 US claimed
EP-2035444-A2 DIPEPTIDE COMPOUNDS CONTAINING D-HISTIDINE Flamma S.P.A. (IT) 2009-03-18 EP claimed
WO-2008001175-A2 DIPEPTIDE COMPOUNDS CONTAINING D-HISTIDINE FLAMMA S.P.A. (IT) 2008-01-03 WO claimed
US-5503776-A PROTECTIVE COATINGS, EMULSIFIERS, BACTERICIDES, ULTRAVIOLET ABSORBERS, CHELATING NATIONAL FOOD RESEARCH INSTITUTE MINISTRY OF AGRICULTURE, FORESTRY AND FISHERIES (JP) 1996-04-02 US claimed
EP-4370115-A1 CARNOSINE ANALOGS FOR USE IN THE TREATMENT OF METABOLIC DISORDERS Nottingham Trent University (GB) 2024-05-22 EP disclosed
CN-117700583-A Preparation method of hyaluronic acid-based biological material 珠海瑞玞生物工程有限公司 2024-03-15 CN disclosed
EP-3691691-B1 PHARMACEUTICAL COMPOSITIONS CONTAINING A CONJUGATE OF HYALURONIC ACID AND CARNOSINE AND RELATIVE USE FIDIA FARM SPA (IT) 2023-12-13 EP disclosed
WO-2023285790-A1 CARNOSINE ANALOGS FOR USE IN THE TREATMENT OF METABOLIC DISORDERS NOTTINGHAM TRENT UNIVERSITY (GB) 2023-01-19 WO disclosed
US-11331305-B2 Peptides for skin rejuvenation and methods of using the same ANTEIS SA (CH) 2022-05-17 US disclosed
US-20220031797-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING HYALURONIC ACID AND CARNOSINE AND RELATIVE USE FIDIA FARMACEUTICI S.P.A. (IT) 2022-02-03 US disclosed
CN-106573957-B Derivatives from hyaluronic acid and carnosine 塞巴斯蒂安诺·舒托 2021-10-26 CN disclosed
US-20130210702-A1 Vitamin E Conjugates, and Their Uses as Antioxidants and Prodrug Delivery Vehicles BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE 2013-08-15 US disclosed
US-20130210702-A1 Vitamin E Conjugates, and Their Uses as Antioxidants and Prodrug Delivery Vehicles BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE 2013-08-15 US disclosed
WO-2011146589-A2 VITAMIN E CONJUGATES, AND THEIR USES AS ANTIOXIDANTS AND PRODRUG DELIVERY VEHICLES BOARD OF SUPERVISORS OF LOUSIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) 2011-11-24 WO disclosed
WO-2011146589-A2 VITAMIN E CONJUGATES, AND THEIR USES AS ANTIOXIDANTS AND PRODRUG DELIVERY VEHICLES BOARD OF SUPERVISORS OF LOUSIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) 2011-11-24 WO disclosed
EP-1860116-A1 Trehalose conjugate with carnosine having antioxidant activity, stable to enzymatic hydrolysis, procedure for its preparation, and pharmaceutical, cosmetic and nutraceutical compositions that contain it Universita' Degli Studi Di Catania (IT) 2007-11-28 EP disclosed
EP-0500332-B1 Novel acylamino acid compounds and a method for their production NAT FOOD RESEARCH INST MINISTR (JP) 1998-05-27 EP disclosed
US-5503776-A PROTECTIVE COATINGS, EMULSIFIERS, BACTERICIDES, ULTRAVIOLET ABSORBERS, CHELATING NATIONAL FOOD RESEARCH INSTITUTE MINISTRY OF AGRICULTURE, FORESTRY AND FISHERIES (JP) 1996-04-02 US disclosed
EP-0500332-A2 Novel acylamino acid compounds and a method for their production NATIONAL FOOD RESEARCH INSTITUTE MINISTRY OF AGRICULTURE, FORESTRY AND FISHERIES (JP) 1992-08-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090306165-A1 DIPEPTIDE COMPOUNDS CONTAINING D-HISTIDINE FOLH1, SLC7A1, HNMT HDAC6 3366/4885HDAC1 3106/4885MEN1 3844/4885
US-20130210702-A1 Vitamin E Conjugates, and Their Uses as Antioxidants and Prodrug Delivery Vehicles TTPA, VSIR, FOLR1 HDAC6 3527/4885HDAC1 2791/4885MEN1 2304/4885
US-11331305-B2 Peptides for skin rejuvenation and methods of using the same CUTA, PLOD3, MMP13 HDAC6 913/4885HDAC1 1776/4885MEN1 2024/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.