Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 9/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | HTT | P42858 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | CYP2B6 | P20813 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Artemisin SCHEMBL13976003 | 1.00 | PTGES2 (1.00) | PTGES2ALDH1A1LMNAHTTCYP1A2 | |
| Artemisin SCHEMBL12741200 | 1.00 | PTGES2 (1.00) | PTGES2ALDH1A1LMNAHTTCYP1A2 | |
| Artemisin SCHEMBL13219259 | 1.00 | PTGES2 (1.00) | PTGES2ALDH1A1LMNAHTTCYP1A2 | |
| Artemisin SCHEMBL23843508 | 1.00 | PTGES2 (1.00) | PTGES2ALDH1A1LMNAHTTCYP1A2 | |
| Artemisin SCHEMBL10042110 | 1.00 | PTGES2 (1.00) | PTGES2ALDH1A1LMNAHTTCYP1A2 | |
| Artemisin SCHEMBL23974927 | 1.00 | PTGES2 (1.00) | PTGES2ALDH1A1LMNAHTTCYP1A2 | |
| Artemisin SCHEMBL14013802 | 1.00 | PTGES2 (1.00) | PTGES2ALDH1A1LMNAHTTCYP1A2 | |
| Artemisin SCHEMBL60303 | 1.00 | PTGES2 (1.00) | PTGES2ALDH1A1LMNAHTTCYP1A2 | |
| Artemisin SCHEMBL10331315 | 1.00 | PTGES2 (1.00) | PTGES2ALDH1A1LMNAHTTCYP1A2 | |
| Artemisin SCHEMBL14616147 | 1.00 | PTGES2 (1.00) | PTGES2ALDH1A1LMNAHTTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9802952-B2 | Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives | Max-Plank-Gesellschaft zur Förderung der Wissenschaften e.v. (DE) | 2017-10-31 | — | — | US | disclosed |
| US-9802952-B2 | Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives | Max-Plank-Gesellschaft zur Förderung der Wissenschaften e.v. (DE) | 2017-10-31 | — | — | US | disclosed |
| US-20170226122-A1 | ARTEMISININ DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTIMALARIAL AGENTS | UNIVERSITY OF ROCHESTER | 2017-08-10 | — | — | US | disclosed |
| EP-2751113-B1 | METHOD AND DEVICE FOR THE SYNTHESIS OF ARTEMISININ | MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V (DE) | 2017-07-05 | — | — | EP | disclosed |
| EP-3022208-B1 | METHOD AND APPARATUS FOR THE SYNTHESIS OF DIHYDROARTEMISININ AND ARTEMISININ DERIVATIVES | MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS (DE) | 2017-06-14 | — | — | EP | disclosed |
| US-9663532-B2 | Artemisinin derivatives, methods for their preparation and their use as antimalarial agents | UNIVERSITY OF ROCHESTER (US) | 2017-05-30 | — | — | US | disclosed |
| US-9409142-B2 | Method and device for the synthesis of artemisinin | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2016-08-09 | — | — | US | disclosed |
| US-9409142-B2 | Method and device for the synthesis of artemisinin | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2016-08-09 | — | — | US | disclosed |
| US-20160145265-A1 | METHOD AND APPARATUS FOR THE SYNTHESIS OF DIHYDROARTEMISININ AND ARTEMISININ DERIVATIVES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2016-05-26 | — | — | US | disclosed |
| US-20160145265-A1 | METHOD AND APPARATUS FOR THE SYNTHESIS OF DIHYDROARTEMISININ AND ARTEMISININ DERIVATIVES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2016-05-26 | — | — | US | disclosed |
| US-20140364630-A1 | METHOD AND DEVICE FOR THE SYNTHESIS OF ARTEMISININ | MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSC (DE) | 2014-12-11 | — | — | US | disclosed |
| US-20140364630-A1 | METHOD AND DEVICE FOR THE SYNTHESIS OF ARTEMISININ | MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSC (DE) | 2014-12-11 | — | — | US | disclosed |
| US-20140329894-A1 | COMBINATION THERAPY AND USES THEREOF FOR TREATMENT AND PREVENTION OF PARASITIC INFECTION AND DISEASE | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY | 2014-11-06 | — | — | US | disclosed |
| US-8815942-B2 | Combination therapy and uses thereof for treatment and prevention of parasitic infection and disease | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2014-08-26 | — | — | US | disclosed |
| US-8815942-B2 | Combination therapy and uses thereof for treatment and prevention of parasitic infection and disease | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2014-08-26 | — | — | US | disclosed |
| WO-2013030247-A1 | METHOD AND DEVICE FOR THE SYNTHESIS OF ARTEMISININ | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2013-03-07 | — | — | WO | disclosed |
| EP-2565197-A1 | Method and device for the synthesis of artemisinin | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2013-03-06 | — | — | EP | disclosed |
| US-20120189567-A1 | Artemisinin Derivatives with Natural Amino Acids, Peptides, and Amino Sugars for Skin Imperfections and Infection in Mammals | BIODERM RESEARCH (US) | 2012-07-26 | — | — | US | disclosed |
| US-20120101151-A1 | COMBINATION THERAPY AND USES THEREOF FOR TREATMENT AND PREVENTION OF PARASITIC INFECTION AND DISEASE | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY | 2012-04-26 | — | — | US | disclosed |
| US-20120101151-A1 | COMBINATION THERAPY AND USES THEREOF FOR TREATMENT AND PREVENTION OF PARASITIC INFECTION AND DISEASE | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY | 2012-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120189567-A1 | Artemisinin Derivatives with Natural Amino Acids, Peptides, and Amino Sugars for Skin Imperfections and Infection in Mammals | CUTA, ROS1, RAB35 | PTGES2 2087/4885ALDH1A1 1501/4885LMNA 4272/4885 |
| US-20140329894-A1 | COMBINATION THERAPY AND USES THEREOF FOR TREATMENT AND PREVENTION OF PARASITIC INFECTION AND DISEASE | CTH, SLC7A11, CBS | PTGES2 213/4885ALDH1A1 777/4885LMNA 3179/4885 |
| US-20170226122-A1 | ARTEMISININ DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTIMALARIAL AGENTS | CYP3A43, CYP3A7, CYP2A7 | PTGES2 327/4885ALDH1A1 207/4885LMNA 1266/4885 |
| US-20160145265-A1 | METHOD AND APPARATUS FOR THE SYNTHESIS OF DIHYDROARTEMISININ AND ARTEMISININ DERIVATIVES | ADH1A, DHODH, DHPS | PTGES2 1162/4885ALDH1A1 24/4885LMNA 1756/4885 |
| US-20140364630-A1 | METHOD AND DEVICE FOR THE SYNTHESIS OF ARTEMISININ | DHFR, DHODH, DHPS | PTGES2 189/4885ALDH1A1 419/4885LMNA 3516/4885 |
| US-20120101151-A1 | COMBINATION THERAPY AND USES THEREOF FOR TREATMENT AND PREVENTION OF PARASITIC INFECTION AND DISEASE | CTH, SLC7A11, CBS | PTGES2 213/4885ALDH1A1 777/4885LMNA 3179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.