Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.85 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.85 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.85 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.85 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.56 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.56 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.56 |
| ▸ | HTR3B | O95264 | 1/20 | 0.56 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.56 |
| ▸ | CHRNG | P07510 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6801764 | 1.00 | CHRNB2 (0.85) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL16130558 | 0.98 | CHRNB2 (0.89) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL2606118 | 0.98 | CHRNB2 (0.89) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL16130578 | 0.98 | CHRNB2 (0.89) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL13238778 | 0.92 | CHRNB2 (1.00) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL155935 | 0.92 | CHRNB2 (1.00) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL15836592 | 0.92 | CHRNB2 (1.00) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL3651888 | 0.91 | CHRNB2 (0.77) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL4294175 | 0.84 | CHRNB2 (0.77) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL12090442 | 0.81 | CHRNB2 (0.64) | CHRNB2CHRNA7CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020169156-A1 | Azacyclooctane and heptane derivatives, their preparation and use in therapy | NEUROSEARCH A/S | 2002-11-14 | — | — | US | claimed |
| US-8741934-B2 | Inhibitors of ion channels | PFIZER LIMITED (GB) | 2014-06-03 | — | — | US | disclosed |
| US-20130072471-A1 | Inhibitors of Ion Channels | MARRON BRIAN EDWARD (US) | 2013-03-21 | — | — | US | disclosed |
| US-8362008-B2 | Amido-thiophene compounds and their use as 11-beta-HSD1 inhibitors | THE UNIVERSITY OF EDINBURGH (GB) | 2013-01-29 | — | — | US | disclosed |
| US-20130012545-A1 | Amido-Thiophene Compounds and Their Use | THE UNIVERSITY OF EDINBURGH (GB) | 2013-01-10 | — | — | US | disclosed |
| US-8299063-B2 | Amido-thiophene compounds and their use | THE UNIVERSITY OF EDINBURGH (GB) | 2012-10-30 | — | — | US | disclosed |
| US-20120095046-A1 | Amido-Isothiazole Compounds and Their Use as Inhibitors of 11Beta-HSD1 for the Treatment of Metabolic Syndrome and Related Disorders | THE UNIVERSITY OF EDINBURGH (GB) | 2012-04-19 | — | — | US | disclosed |
| US-20100267696-A1 | Amido-Thiophene Compounds and Their Use as 11-Beta-HSD1 Inhibitors | THE UNIVERSITY OF EDINBURGH | 2010-10-21 | — | — | US | disclosed |
| EP-1995241-A1 | Inhibitors of ion channels | ICAgen, Incorporated (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2008118758-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (GB) | 2008-10-02 | — | — | WO | disclosed |
| US-6680314-B2 | USEFUL FOR THE TREATMENT OF DISEASES INVOLVING THE CHOLINERGIC SYSTEM OF THE CENTRAL NERVOUS SYSTEM, PAIN, INFLAMMATORY DISEASES, DISEASES CAUSED BY SMOOTH MUSCLE CONTRACTIONS, LEARNING DEFICIT, COGNITION DEFICIT, ATTENTION DEFICIT | NEUROSEARCH A/S (DK) | 2004-01-20 | — | — | US | disclosed |
| EP-0984943-B1 | AZACYCLOOCTANE AND HEPTANE DERIVATIVES, THEIR PREPARATION AND USEIN THERAPY | NEUROSEARCH AS (DK) | 2002-12-11 | — | — | EP | disclosed |
| US-20020169156-A1 | Azacyclooctane and heptane derivatives, their preparation and use in therapy | NEUROSEARCH A/S | 2002-11-14 | — | — | US | disclosed |
| US-6420395-B1 | DISORDERS OR DISEASES INVOLVING THE CHOLINERGIC SYSTEM OF THE CENTRAL NERVOUS SYSTEM, PAIN, INFLAMMATORY DISEASES, DISEASES CAUSED BY SMOOTH MUSCLE CONTRACTIONS AND AS ASSISTANCE IN THE CESSATION OF CHEMICAL SUBSTANCE ABUSE. | NEUROSEARCH A/S (DK) | 2002-07-16 | — | — | US | disclosed |
| US-5496943-A | USING UNSATURATED ACYLISOCYANATE COMPOUNDS TO FORM OXAZOLINES, PYRANS WITH AMINOCARBONYLHETERO SUBSTITUTION AND GLUTARIMIDE DERIVATIVES AS CHEMICAL INTERMEDIATES | NIPPON PAINT CO., LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0503958-A2 | Heterocyclic compounds and their production | Nippon Paint Co., Ltd. (JP) | 1992-09-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095046-A1 | Amido-Isothiazole Compounds and Their Use as Inhibitors of 11Beta-HSD1 for the Treatment of Metabolic Syndrome and Related Disorders | HSD11B1, HSD11B2, HSD3B1 | CHRNB2 1125/4885CHRNA7 1599/4885CHRNA4 1993/4885 |
| US-20130072471-A1 | Inhibitors of Ion Channels | TRPV1, TRPV5, TRPA1 | CHRNB2 469/4885CHRNA7 405/4885CHRNA4 340/4885 |
| US-20100267696-A1 | Amido-Thiophene Compounds and Their Use as 11-Beta-HSD1 Inhibitors | HSD11B1, HSD11B2, HSD17B1 | CHRNB2 1944/4885CHRNA7 3035/4885CHRNA4 3198/4885 |
| US-20020169156-A1 | Azacyclooctane and heptane derivatives, their preparation and use in therapy | CHRNA1, CHRNB1, CHRNA3 | CHRNB2 17/4885CHRNA7 5/4885CHRNA4 19/4885 |
| US-20130012545-A1 | Amido-Thiophene Compounds and Their Use | HSD11B1, HSD11B2, HSD17B1 | CHRNB2 1734/4885CHRNA7 2734/4885CHRNA4 2831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.