Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | THRB | P10828 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | PLG | P00747 | 1/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.68 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.68 |
| ▸ | RECQL | P46063 | 1/20 | 0.68 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | BLM | P54132 | 2/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL11416033 | 1.00 | LMNA (0.68) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| Terephthalic Acid SCHEMBL262199 | 1.00 | LMNA (0.68) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| Stearic Acid SCHEMBL15899228 | 0.91 | GPR84 (0.57) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| Aminomethylbenzoic Acid SCHEMBL1201553 | 0.91 | KMT2A (0.57) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| Aminomethylbenzoic Acid SCHEMBL9523091 | 0.91 | KMT2A (0.57) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| Terephthalic Acid SCHEMBL7550600 | 0.90 | LMNA (0.55) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| Terephthalic Acid SCHEMBL337710 | 0.89 | TSHR (0.60) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| Azelaic Acid SCHEMBL351913 | 0.89 | LMNA (0.60) | LMNANFKB1TSHRHDAC3HDAC4 | |
| Terephthalic Acid SCHEMBL7046508 | 0.89 | TSHR (0.60) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| Terephthalic Acid SCHEMBL11145819 | 0.89 | LMNA (0.60) | LMNANFKB1TSHRHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200392316-A1 | VULCANIZED HNBR PRODUCT WITH IMPROVED HOT AIR | ARLANXEO DEUTSCHLAND GMBH (DE) | 2020-12-17 | — | — | US | disclosed |
| CN-111492002-A | Cured HNBR products having improved hot air resistance | 阿朗新科德国有限责任公司 | 2020-08-04 | — | — | CN | disclosed |
| US-10350865-B2 | Multilayer film with polyamide and polyester layers for the production of photovoltaic modules | EVONIK DEGUSSA GMBH (DE) | 2019-07-16 | — | — | US | disclosed |
| US-10239293-B2 | Composite part | LANXESS DEUTSCHLAND GMBH (DE) | 2019-03-26 | — | — | US | disclosed |
| US-20180080586-A1 | MULTILAYER HOLLOW BODY HAVING HIGH LEACHING RESISTANCE | EVONIK DEGUSSA GMBH (DE) | 2018-03-22 | — | — | US | disclosed |
| US-9919494-B2 | Metallic pipe having a hydrolysis-resistant layer of a polyamide moulding composition | EVONIK DEGUSSA GMBH (DE) | 2018-03-20 | — | — | US | disclosed |
| US-20170349749-A1 | COMPOSITE | LANXESS DEUTSCHLAND GMBH (DE) | 2017-12-07 | — | — | US | disclosed |
| US-20170320301-A1 | COMPOSITE PART | LANXESS DEUTSCHLAND GMBH (DE) | 2017-11-09 | — | — | US | disclosed |
| US-20160060459-A1 | METALLIC PIPE HAVING A HYDROLYSIS-RESISTANT LAYER OF A POLYAMIDE MOULDING COMPOSITION | EVONIK DEGUSSA GMBH (DE) | 2016-03-03 | — | — | US | disclosed |
| US-20150306854-A1 | COMPOSITE PART | LANXESS DEUTSCHLAND GMBH (DE) | 2015-10-29 | — | — | US | disclosed |
| US-6677015-B2 | POLYAMINE/AMIDE COPOLYMER HAVING HIGH MELT STIFFNESS; EASY CUTTING | DEGUSSA AG (DE) | 2004-01-13 | — | — | US | disclosed |
| US-6660796-B2 | Anhydride group-containing ethylene-alpha-olefin copolymer or styrene-ethylene/butylene block copolymer as impact modifier; ethylene-acrylic monomer terpolymer | DEGUSSA AG (DE) | 2003-12-09 | — | — | US | disclosed |
| US-6579581-B2 | Molding materials; polyamide and addition polymer blend | DEGUSSA AG (DE) | 2003-06-17 | — | — | US | disclosed |
| US-6538073-B1 | Polyamide graft copolymers | DEGUSSA AG (DE) | 2003-03-25 | — | — | US | disclosed |
| US-20020142118-A1 | Injection molding, blow molding, coextrusion | DEGUSSA AG (DE) | 2002-10-03 | — | — | US | disclosed |
| US-20020119272-A1 | Polycaprolactam/polyhexamethylene adipamide multilayer composites for use as moldings for fuel, oil or heat lines on motor vehicles; chemical resistance | DEGUSSA AG (DE) | 2002-08-29 | — | — | US | disclosed |
| US-20020119267-A1 | Polyamine/amide copolymer having high melt stiffness; easy cutting | DEGUSSA AG (DE) | 2002-08-29 | — | — | US | disclosed |
| US-20020115771-A1 | Polyester molding composition | DEGUSSA AG (DE) | 2002-08-22 | — | — | US | disclosed |
| US-6355358-B1 | FOR FUEL TANK, A FILLER NECK, OR A FUEL TANK FILLER NECK, PIPE LINES | DEGUSSA AG (DE) | 2002-03-12 | — | — | US | disclosed |
| US-20020019477-A1 | Molding materials; polyamide and addition polymer blend | DEGUSSA-HUELS AKTIENGESELLSCHAFT (DE) | 2002-02-14 | — | — | US | disclosed |