Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | THRB | P10828 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | PLG | P00747 | 1/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.68 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.68 |
| ▸ | RECQL | P46063 | 1/20 | 0.68 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | BLM | P54132 | 2/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL11416033 | 1.00 | LMNA (0.68) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| Terephthalic Acid SCHEMBL261197 | 1.00 | LMNA (0.68) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| Stearic Acid SCHEMBL15899228 | 0.91 | GPR84 (0.57) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| Aminomethylbenzoic Acid SCHEMBL1201553 | 0.91 | KMT2A (0.57) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| Aminomethylbenzoic Acid SCHEMBL9523091 | 0.91 | KMT2A (0.57) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| Terephthalic Acid SCHEMBL7550600 | 0.90 | LMNA (0.55) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| Terephthalic Acid SCHEMBL337710 | 0.89 | TSHR (0.60) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| Azelaic Acid SCHEMBL351913 | 0.89 | LMNA (0.60) | LMNANFKB1TSHRHDAC3HDAC4 | |
| Terephthalic Acid SCHEMBL7046508 | 0.89 | TSHR (0.60) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| Terephthalic Acid SCHEMBL11145819 | 0.89 | LMNA (0.60) | LMNANFKB1TSHRHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020084654-A1 | Resin connector | TOKAI RUBBER INDUSTRIES, LTD. (JP) | 2002-07-04 | — | — | US | claimed |
| US-3944708-A | POLYAMIDE, POLYESTER OR POLYOLEFIN | RHONE-POULENC TEXTILE (FR) | 1976-03-16 | — | — | US | claimed |
| CN-110283457-B | Polyarylene sulfide resin composition, molded article thereof, and surface mount electronic component | DIC株式会社 | 2023-03-31 | — | — | CN | disclosed |
| CN-109096761-B | Polyarylene sulfide resin composition, molded article thereof, and electric vehicle component | DIC株式会社 | 2021-05-11 | — | — | CN | disclosed |
| US-10982049-B2 | Polyarylene sulfide resin and manufacturing method therefor, poly(arylene sulfonium salt) and manufacturing method therefor, and sulfoxide | DIC CORPORATION (JP) | 2021-04-20 | — | — | US | disclosed |
| US-20200392316-A1 | VULCANIZED HNBR PRODUCT WITH IMPROVED HOT AIR | ARLANXEO DEUTSCHLAND GMBH (DE) | 2020-12-17 | — | — | US | disclosed |
| EP-3042924-B1 | POLYARYLENE SULFIDE RESIN AND MANUFACTURING METHOD THEREFOR, POLY(ARYLENE SULFONIUM SALT) AND MANUFACTURING METHOD THEREFOR, AND SULFOXIDE | DAINIPPON INK & CHEMICALS (JP) | 2020-04-29 | — | — | EP | disclosed |
| EP-3636632-A1 | POLYARYLENE SULFIDE RESIN AND MANUFACTURING METHOD THEREFOR, POLY(ARYLENESULFONIUM SALT) AND MANUFACTURING METHOD THEREFOR, AND SULFOXIDE | DIC Corporation (JP) | 2020-04-15 | — | — | EP | disclosed |
| US-20190300652-A1 | POLYARYLENE SULFIDE RESIN AND MANUFACTURING METHOD THEREFOR, POLY(ARYLENE SULFONIUM SALT) AND MANUFACTURING METHOD THEREFOR, AND SULFOXIDE | DAINIPPON INK & CHEMICALS (JP) | 2019-10-03 | — | — | US | disclosed |
| US-10385168-B2 | Polyarylene sulfide resin and manufacturing method therefor, poly(arylenesulfonium salt) and manufacturing method therefor, and sulfoxide | DIC CORPORATION (JP) | 2019-08-20 | — | — | US | disclosed |
| US-10350865-B2 | Multilayer film with polyamide and polyester layers for the production of photovoltaic modules | EVONIK DEGUSSA GMBH (DE) | 2019-07-16 | — | — | US | disclosed |
| US-20020019477-A1 | Molding materials; polyamide and addition polymer blend | DEGUSSA-HUELS AKTIENGESELLSCHAFT (DE) | 2002-02-14 | — | — | US | disclosed |
| EP-0668312-B1 | Recycling methods of resin compositions | GEN ELECTRIC (US) | 2000-05-24 | — | — | EP | disclosed |
| EP-0707046-B1 | A thermoplastic resin composition | GEN ELECTRIC (US) | 2000-05-03 | — | — | EP | disclosed |
| US-6010760-A | BLENDING THERMOPLASTIC RESIN AND LIQUID CRYSTALLINE POLYMER; FORMING ANISOTROPIC MELT; KNEADING | POLYPLASTICS CO., LTD. (JP) | 2000-01-04 | — | — | US | disclosed |
| EP-0790280-A1 | THERMOPLASTIC RESIN COMPOSITION, INJECTION MOLDING METHOD THEREOF AND INJECTION MOLDED ARTICLE | POLYPLASTICS CO. LTD. (JP) | 1997-08-20 | — | — | EP | disclosed |
| US-5554693-A | Compositions of polyphenylene ether and polyamide resins containing terpene phenol resins | GENERAL ELECTRIC COMPANY (US) | 1996-09-10 | — | — | US | disclosed |
| EP-0707046-A2 | A thermoplastic resin composition | GENERAL ELECTRIC COMPANY (US) | 1996-04-17 | — | — | EP | disclosed |
| EP-0668312-A1 | Recycling methods of resin compositions | GENERAL ELECTRIC COMPANY (US) | 1995-08-23 | — | — | EP | disclosed |
| US-3926924-A | Polyamide copolymers from hexamethylene diammonium adipate/terephthalate and a third polyamide forming reactant | ICI LTD | 1975-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190300652-A1 | POLYARYLENE SULFIDE RESIN AND MANUFACTURING METHOD THEREFOR, POLY(ARYLENE SULFONIUM SALT) AND MANUFACTURING METHOD THEREFOR, AND SULFOXIDE | GARS1, ASH2L, SULT1A1 | LMNA 4748/4885THRB 3501/4885KMT2A 1522/4885 |
| US-10982049-B2 | Polyarylene sulfide resin and manufacturing method therefor, poly(arylene sulfonium salt) and manufacturing method therefor, and sulfoxide | GARS1, ASH2L, SULT1A1 | LMNA 4748/4885THRB 3501/4885KMT2A 1522/4885 |
| US-10385168-B2 | Polyarylene sulfide resin and manufacturing method therefor, poly(arylenesulfonium salt) and manufacturing method therefor, and sulfoxide | GARS1, ASH2L, SULT1A1 | LMNA 4730/4885THRB 3494/4885KMT2A 1438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.