SCHEMBL26335692

SCHEMBL26335692

CNC(=O)c1c(Cl)c(=O)oc2ccccc12

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.48
CA9 Q16790 2/20 0.48
ALDH1A1 P00352 6/20 0.44
KDM4E B2RXH2 5/20 0.44
MAPT P10636 4/20 0.44
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
POLB P06746 1/20 0.43
NQO1 P15559 3/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
LMNA P02545 2/20 0.43
ABCB11 O95342 1/20 0.43
TP53 P04637 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
TSHR P16473 1/20 0.43
MAPK1 P28482 1/20 0.43
CYP2C19 P33261 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26348265 0.84 MAOA (0.52) CA12CA9ALDH1A1KDM4EMAPT
SCHEMBL26335570 0.83 CA12 (0.56) CA12CA9ALDH1A1KDM4EMAPT
SCHEMBL17169389 0.80 CA12 (0.69) CA12CA9ALDH1A1KDM4EMAPT
SCHEMBL26338052 0.79 CA12 (0.46) CA12CA9ALDH1A1KDM4EMAPT
SCHEMBL3263341 0.78 CYP2C19 (0.58) ALDH1A1KDM4ENPC1RAB9ACYP2C9
SCHEMBL2540914 0.73 ALDH1A1 (0.53) CA12CA9ALDH1A1KDM4EMAPT
SCHEMBL27752820 0.72 HSD17B3 (0.60) ALDH1A1KDM4EMAPTPOLBKMT2A
SCHEMBL27752675 0.72 KDM4E (0.62) CA12CA9ALDH1A1KDM4EMAPT
SCHEMBL6119706 0.72 ACHE (0.48) ALDH1A1KDM4EMAPTNPC1RAB9A
SCHEMBL27534867 0.71 KDM4E (0.50) CA12CA9ALDH1A1KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4249480-A1 DIPHENYLPYRAZOLE COMPOUND, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Northwest A&F University (CN) 2023-09-27 EP disclosed