Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | LDHB | P07195 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3032522 | 0.83 | CXCR2 (0.47) | TSHRALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL27491094 | 0.80 | ALDH1A1 (0.78) | TSHRALDH1A1TRPA1GABRA1GABRB2 | |
| Cyanate SCHEMBL27968920 | 0.78 | ALDH1A1 (0.74) | TSHRALDH1A1TRPA1GABRA1GABRB2 | |
| SCHEMBL2809868 | 0.77 | ALDH1A1 (0.56) | TSHRALDH1A1TRPA1GABRA1GABRB2 | |
| SCHEMBL6273994 | 0.77 | ALDH1A1 (0.56) | TSHRALDH1A1TRPA1GABRA1GABRB2 | |
| Water SCHEMBL28111086 | 0.77 | ALDH1A1 (0.93) | TSHRALDH1A1TRPA1GABRA1GABRB2 | |
| SCHEMBL31609682 | 0.76 | ALDH1A1 (0.52) | TSHRALDH1A1TRPA1KDM4EHPGD | |
| SCHEMBL491433 | 0.76 | ALDH1A1 (0.52) | TSHRALDH1A1TRPA1KDM4EHPGD | |
| SCHEMBL21173600 | 0.76 | ESR2 (0.52) | TSHRALDH1A1KDM4ECXCR2ESR2 | |
| SCHEMBL21022697 | 0.76 | TSHR (0.65) | TSHRALDH1A1KDM4ECYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115279749-A | SHP2 inhibitor and composition and application thereof | 贝达药业股份有限公司 | 2022-11-01 | — | — | CN | claimed |
| US-20250263386-A1 | Charged Ion Channel Blockers and Methods for Use | NOCION THERAPEUTICS INC (US) | 2025-08-21 | — | — | US | disclosed |
| US-20250257076-A1 | SUBSTITUTED PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES AS cGAS INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2025-08-14 | — | — | US | disclosed |
| US-20250197388-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY BOWEL DISEASE | EMPRESS THERAPEUTICS, INC. | 2025-06-19 | — | — | US | disclosed |
| CN-119487012-A | Compounds, pharmaceutical compositions and methods for treating inflammatory bowel disease | 旗舰创业创新六公司 | 2025-02-18 | — | — | CN | disclosed |
| US-20250049772-A1 | PIPERIDINYL-3-(ARYLOXY)PROPANAMIDES AND PROPANOATES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2025-02-13 | — | — | US | disclosed |
| EP-4499618-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY BOWEL DISEASE | Flagship Pioneering Innovations VI, LLC (US) | 2025-02-05 | — | — | EP | disclosed |
| CN-119118953-A | Charged ion channel blockers and methods of use thereof | 诺西恩医疗公司 | 2024-12-13 | — | — | CN | disclosed |
| US-12162851-B2 | Charged ion channel blockers and methods for use | Nocion Therapeutics, Inc. (US) | 2024-12-10 | — | — | US | disclosed |
| CN-115279731-B | Charged ion channel blockers and methods of use thereof | 诺西恩医疗公司 | 2024-09-13 | — | — | CN | disclosed |
| US-6194454-B1 | ANTILIPEMIC AGENTS; ANTIDIABETIC AGENTS; DIETETICS; RHEUMATIC DISEASES; ANTICHOLESTEROL AGENTS; CARDIOVASCULAR DISORDERS; ANTIDEPRESSANTS; BONE DISORDERS | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-1033364-A1 | Cyano containing oxamic acids and derivatives as thyroid receptor ligands | Pfizer Products Inc. (US) | 2000-09-06 | — | — | EP | disclosed |
| EP-0569795-B1 | Sulphonylbenzyl substituted benzo- and pyridopyridones | BAYER AG (DE) | 1995-04-12 | — | — | EP | disclosed |
| EP-0569794-A1 | Biphenylmethyl-substituted pyridones useful as angiotensin II receptor antagonists. | BAYER AG (DE) | 1993-11-18 | — | — | EP | disclosed |
| EP-0569795-A1 | Sulphonylbenzyl substituted benzo- and pyridopyridones | BAYER AG (DE) | 1993-11-18 | — | — | EP | disclosed |
| US-5198439-A | Hypotensive agents, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-03-30 | — | — | US | disclosed |
| US-5130318-A | Hypotensive agents and for treatment of congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-14 | — | — | US | disclosed |
| EP-0453210-A2 | Pyridine derivatives | ZENECA LIMITED (GB) | 1991-10-23 | — | — | EP | disclosed |
| EP-0365763-A1 | Antiproliferative cyclic compounds | AGOURON PHARMACEUTICALS, INC. (US) | 1990-05-02 | — | — | EP | disclosed |
| US-4184013-A | Electrochemical storage cell | BROWN, BOVERI & CIE AG (DE) | 1980-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12162851-B2 | Charged ion channel blockers and methods for use | TRPV1, TRPV5, TRPV2 | TSHR 3619/4885ALDH1A1 2437/4885TRPA1 10/4885 |
| US-20250263386-A1 | Charged Ion Channel Blockers and Methods for Use | TRPV1, TRPV5, TRPV2 | TSHR 3619/4885ALDH1A1 2437/4885TRPA1 10/4885 |
| US-20250049772-A1 | PIPERIDINYL-3-(ARYLOXY)PROPANAMIDES AND PROPANOATES | SSTR4, SSTR3, NPY4R | TSHR 24/4885ALDH1A1 1476/4885TRPA1 1559/4885 |
| US-20250197388-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY BOWEL DISEASE | SI, VIP, APC | TSHR 4822/4885ALDH1A1 3871/4885TRPA1 587/4885 |
| US-20250257076-A1 | SUBSTITUTED PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES AS cGAS INHIBITORS | CGAS, SSB, FPGS | TSHR 3160/4885ALDH1A1 1529/4885TRPA1 3827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.