Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | MC4R | P32245 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10848836 | 1.00 | ALDH1A1 (0.50) | ALDH1A1HPGDHSD17B10MAPTPKM | |
| SCHEMBL2077862 | 0.98 | ALDH1A1 (0.47) | ALDH1A1HPGDHSD17B10MAPTPKM | |
| SCHEMBL30002131 | 0.98 | ALDH1A1 (0.47) | ALDH1A1HPGDHSD17B10MAPTPKM | |
| SCHEMBL24130978 | 0.94 | ALDH1A1 (0.43) | ALDH1A1HPGDHSD17B10MAPTPKM | |
| SCHEMBL26931611 | 0.90 | GAA (0.46) | ALDH1A1HPGDHSD17B10MAPTPKM | |
| SCHEMBL30728974 | 0.90 | GAA (0.46) | ALDH1A1HPGDHSD17B10MAPTPKM | |
| SCHEMBL32665351 | 0.82 | HRH1 (0.46) | ALDH1A1HPGDHSD17B10MAPTPKM | |
| SCHEMBL4863817 | 0.82 | GAA (0.40) | ALDH1A1HPGDHSD17B10MAPTPKM | |
| SCHEMBL2184889 | 0.82 | HRH1 (0.46) | ALDH1A1HPGDHSD17B10MAPTPKM | |
| SCHEMBL30137583 | 0.82 | GAA (0.40) | ALDH1A1HPGDHSD17B10MAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902248-B2 | C-(Heteroarylaminocarbonyl)-3-phenyl-oxime, e.g., N-Benzothiazol-2-yl-2-(3-chloro-4-methanesulfonyl-phenyl)-2-isopropoxyiminoacetamide and 2-(3-Chloro-4-methanesulfonyl-phenyl)-2-cyclopentyloxyimino-N-(5-methyl-thiazol-2-yl)acetamide; treating metabolic diseases, especially type II diabetes mellitus | HOFFMANN-LA ROCHE INC. (US) | 2011-03-08 | — | — | US | disclosed |
| EP-1273343-B1 | METHOD OF SEPARATING IMIDE COMPOUND | DAICEL CHEM (JP) | 2010-11-24 | — | — | EP | disclosed |
| US-20100226875-A1 | CONTROLLED RELEASE OF ACTIVE COMPOUNDS FROM DYNAMIC MIXTURES | FIRMENICH SA (CH) | 2010-09-09 | — | — | US | disclosed |
| EP-2010293-A2 | CONTROLLED RELEASE OF ACTIVE COMPOUNDS FROM DYNAMIC MIXTURES | Firmenich S.A. (CH) | 2009-01-07 | — | — | EP | disclosed |
| US-7419967-B2 | Sulfonamide inhibitors of aspartyl protease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-09-02 | — | — | US | disclosed |
| US-7419967-B2 | Sulfonamide inhibitors of aspartyl protease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-09-02 | — | — | US | disclosed |
| US-7419967-B2 | Sulfonamide inhibitors of aspartyl protease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-09-02 | — | — | US | disclosed |
| US-20080146625-A1 | C-(Heteroarylaminocarbonyl)-3-phenyl-oxime, e.g., N-Benzothiazol-2-yl-2-(3-chloro-4-methanesulfonyl-phenyl)-2-isopropoxyiminoacetamide and 2-(3-Chloro-4-methanesulfonyl-phenyl)-2-cyclopentyloxyimino-N-(5-methyl-thiazol-2-yl)acetamide; treating metabolic diseases, especially type II diabetes mellitus | BERTHEL STEVEN JOSEPH | 2008-06-19 | — | — | US | disclosed |
| US-7285684-B2 | Process for separating imide compounds | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 2007-10-23 | — | — | US | disclosed |
| WO-2007085991-A2 | CONTROLLED RELEASE OF ACTIVE COMPOUNDS FROM DYNAMIC MIXTURES | FIRMENICH SA (CH) | 2007-08-02 | — | — | WO | disclosed |
| US-20060172936-A1 | Sulfonamide inhibitors of aspartyl protease | VERTEX PHARMACEUTICALS INCORPORATED | 2006-08-03 | — | — | US | disclosed |
| EP-1086076-B1 | SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE | VERTEX PHARMA (US) | 2004-12-22 | — | — | EP | disclosed |
| US-20040097594-A1 | Sulfonamide inhibitors of aspartyl protease | HALE MICHAEL ROBIN (US) | 2004-05-20 | — | — | US | disclosed |
| US-6613743-B2 | Administering to a patient suffering from viral infections a sulfonamides antiviral agents which are aspartyl protease inhibitors | VERTEX PHARMACEUTICALS INCORPORATED | 2003-09-02 | — | — | US | disclosed |
| EP-1273343-A1 | METHOD OF SEPARATING IMIDE COMPOUND | Daicel Chemical Industries, Ltd. (JP) | 2003-01-08 | — | — | EP | disclosed |
| US-20020169331-A1 | Method of separating imide compound | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 2002-11-14 | — | — | US | disclosed |
| US-20020049201-A1 | Sulfonamide inhibitors of aspartyl protease | VERTEX PHARMACEUTICALS INCORPORATED | 2002-04-25 | — | — | US | disclosed |
| EP-1086076-A1 | SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE | Vertex Pharmaceuticals Incorporated (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999065870-A2 | SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1999-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097594-A1 | Sulfonamide inhibitors of aspartyl protease | SPINT2, PRSS1, DNPEP | ALDH1A1 1841/4885HPGD 2994/4885HSD17B10 1425/4885 |
| US-20060172936-A1 | Sulfonamide inhibitors of aspartyl protease | SPINT2, PRSS1, DNPEP | ALDH1A1 1841/4885HPGD 2994/4885HSD17B10 1425/4885 |
| US-20020049201-A1 | Sulfonamide inhibitors of aspartyl protease | SPINT2, PRSS1, DNPEP | ALDH1A1 1841/4885HPGD 2994/4885HSD17B10 1425/4885 |
| US-20020169331-A1 | Method of separating imide compound | ADH1A, SI, CYP2E1 | ALDH1A1 942/4885HPGD 1252/4885HSD17B10 190/4885 |
| US-20100226875-A1 | CONTROLLED RELEASE OF ACTIVE COMPOUNDS FROM DYNAMIC MIXTURES | HPD, TRHDE, BPHL | ALDH1A1 953/4885HPGD 192/4885HSD17B10 694/4885 |
| US-20080146625-A1 | C-(Heteroarylaminocarbonyl)-3-phenyl-oxime, e.g., N-Benzothiazol-2-yl-2-(3-chloro-4-methanesulfonyl-phenyl)-2-isopropoxyiminoacetamide and 2-(3-Chloro-4-methanesulfonyl-phenyl)-2-cyclopentyloxyimino-N-(5-methyl-thiazol-2-yl)acetamide; treating metabolic diseases, especially type II diabetes mellitus | GCK, PC, PCK2 | ALDH1A1 757/4885HPGD 758/4885HSD17B10 678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.