Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30688482 | 0.82 | KDM4E (0.43) | MAPK1SMN1; SMN2HDAC3ADRA1AHDAC4 | |
| SCHEMBL22436411 | 0.82 | KDM4E (0.43) | MAPK1SMN1; SMN2HDAC3ADRA1AHDAC4 | |
| SCHEMBL26447174 | 0.77 | GABRA1 (0.38) | MAPK1SMN1; SMN2MAPTKDM4EEGFR | |
| SCHEMBL26447187 | 0.77 | MAPT (0.39) | MAPK1SMN1; SMN2HDAC4MAPTKDM4E | |
| SCHEMBL7103281 | 0.77 | SMN1; SMN2 (0.59) | MAPK1SMN1; SMN2HDAC3ADRA1AHDAC4 | |
| SCHEMBL30688506 | 0.77 | SMN1; SMN2 (0.59) | MAPK1SMN1; SMN2HDAC3ADRA1AHDAC4 | |
| SCHEMBL20413818 | 0.77 | OPRM1 (0.38) | MAPK1SMN1; SMN2CYP1A2MAPTCYP2C19 | |
| SCHEMBL13491997 | 0.76 | HDAC4 (0.59) | MAPK1SMN1; SMN2HDAC3ADRA1AHDAC4 | |
| SCHEMBL9633674 | 0.76 | KEAP1 (0.52) | FFAR1ALDH1A1RECQL | |
| SCHEMBL26447193 | 0.76 | NOS1 (0.42) | MAPK1SMN1; SMN2MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12024531-B2 | Immunoproteasome inhibitors | PRINCIPIA BIOPHARMA INC. (US) | 2024-07-02 | — | — | US | disclosed |
| US-20230133165-A1 | IMMUNOPROTEASOME INHIBITORS | PRINCIPIA BIOPHARMA INC. | 2023-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12024531-B2 | Immunoproteasome inhibitors | PSMC2, PSMB7, PSMB2 | MAPK1 2047/4885SMN1; SMN2 1269/4885HDAC3 404/4885 |
| US-20230133165-A1 | IMMUNOPROTEASOME INHIBITORS | PSMC2, PSMB7, PSMB2 | MAPK1 2047/4885SMN1; SMN2 1269/4885HDAC3 404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.