Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.47 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.47 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.45 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.45 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.45 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | VNN1 | O95497 | 7/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | P4HB | P07237 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10659911 | 0.81 | VNN1 (0.56) | TAS1R3TAS1R1TAS1R2KCNQ3KCNQ2 | |
| SCHEMBL78878 | 0.79 | TAS1R3 (0.54) | TAS1R3TAS1R1TAS1R2KCNQ3KCNQ2 | |
| SCHEMBL31438988 | 0.79 | TAS1R3 (0.54) | TAS1R3TAS1R1TAS1R2KCNQ3KCNQ2 | |
| SCHEMBL9501454 | 0.79 | RAB9A (0.48) | — | |
| SCHEMBL8780278 | 0.79 | CES2 (0.61) | KCNQ3KCNQ2KCNE1KCNQ1ALDH1A1 | |
| SCHEMBL2577750 | 0.78 | TAS1R3 (0.49) | TAS1R3TAS1R1TAS1R2KCNQ3KCNQ2 | |
| SCHEMBL759728 | 0.78 | KCNQ3 (0.54) | TAS1R3TAS1R1TAS1R2KCNQ3KCNQ2 | |
| SCHEMBL14012598 | 0.78 | KIF11 (0.60) | TAS1R3TAS1R1TAS1R2KCNQ3KCNQ2 | |
| SCHEMBL29421493 | 0.78 | KIF11 (0.60) | TAS1R3TAS1R1TAS1R2KCNQ3KCNQ2 | |
| SCHEMBL30641942 | 0.78 | VNN1 (0.54) | TAS1R3TAS1R1TAS1R2KCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6969716-B2 | 5-phenyl[1,2,4]triazines as ligands for GABA-A α2/α3 receptors for treating anxiety or depression | MERCK SHARP & DOHME LTD. | 2005-11-29 | — | — | US | disclosed |
| US-20040192692-A1 | 5-Phenyl[1,2,4]triazines as ligands for GABA-A alpha2/alpha3 receptors for treating anxiety or depression | MERCK SHARP & DOHME, LTD. (GB) | 2004-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192692-A1 | 5-Phenyl[1,2,4]triazines as ligands for GABA-A alpha2/alpha3 receptors for treating anxiety or depression | GABRA1, GABRA5, GABRA2 | TAS1R3 566/4885TAS1R1 465/4885TAS1R2 500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.