Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 5/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 2/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | UBE2M | P61081 | 1/20 | 0.32 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 2/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | CIT | O14578 | 1/20 | 0.31 |
| ▸ | GAK | O14976 | 1/20 | 0.31 |
| ▸ | PRKX | P51817 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26465703 | 0.87 | CACNA1H (0.40) | CACNA1HWNT3AEPHX2LMNA | |
| SCHEMBL26465821 | 0.87 | CACNA1H (0.41) | CACNA1HHSD11B1HSD11B2WNT3AIDO1 | |
| SCHEMBL26464642 | 0.87 | CACNA1H (0.44) | CACNA1HIDO1LMNASMN1; SMN2 | |
| SCHEMBL26466912 | 0.83 | CACNA1H (0.38) | CACNA1HWNT3ABACE1EPHX2 | |
| SCHEMBL26465825 | 0.78 | ALDH1A1 (0.44) | CACNA1HLMNASMN1; SMN2 | |
| SCHEMBL26464489 | 0.77 | CACNA1H (0.38) | CACNA1HWNT3A | |
| SCHEMBL26465693 | 0.76 | CACNA1H (0.41) | CACNA1HWNT3AEPHX2 | |
| SCHEMBL26465818 | 0.74 | CACNA1H (0.42) | CACNA1HLMNATP53SMN1; SMN2 | |
| SCHEMBL26467001 | 0.74 | LTA4H (0.38) | CACNA1HLMNATP53SMN1; SMN2 | |
| SCHEMBL26465696 | 0.74 | CACNA1H (0.44) | CACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192669-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING A PIPERAZINE OR 1,4-DIAZEPANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |