Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4154487 | 0.88 | KDM5A (0.53) | ALDH1A1HPGDKDM4EPTGS2PDE4D | |
| SCHEMBL10275659 | 0.77 | ALDH1A1 (0.56) | ALDH1A1HPGDKDM4EHSD17B10PTGS2 | |
| SCHEMBL11307581 | 0.74 | KDM4E (0.72) | ALDH1A1HPGDKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL8196859 | 0.73 | PTGS2 (0.84) | ALDH1A1PTGS2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1143334 | 0.71 | ALDH1A1 (1.00) | ALDH1A1HPGDSMN1; SMN2RAB9AMAPT | |
| SCHEMBL11164924 | 0.70 | KDM5A (0.49) | ALDH1A1HPGDKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL4506277 | 0.69 | LMNA (0.65) | ALDH1A1HPGDKDM4EHSD17B10PDE4D | |
| SCHEMBL561576 | 0.69 | KDM5A (0.57) | ALDH1A1HPGDKDM4ERAB9AHIF1A | |
| SCHEMBL4158040 | 0.69 | MEN1 (0.46) | ALDH1A1KDM4EPTGS2RAB9AHIF1A | |
| SCHEMBL2644551 | 0.69 | RAB9A (0.49) | ALDH1A1HPGDHSD17B10SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6541484-B2 | Central nervous system disorders; psychological disorders | MERCK SHARP & DOHME LIMITED | 2003-04-01 | — | — | US | disclosed |
| US-20030004180-A1 | Pyrazolo-pyridine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. (GB) | 2003-01-02 | — | — | US | disclosed |
| EP-1244659-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001044244-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2001-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030004180-A1 | Pyrazolo-pyridine derivatives as ligands for gaba receptors | GABRA3, GABRA4, GABRB3 | ALDH1A1 1355/4885HPGD 2569/4885KDM4E 2289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.