Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CHAT | P28329 | 2/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3630769 | 0.78 | — | — | |
| SCHEMBL5540674 | 0.77 | NFE2L2 (0.44) | ALDH1A1CYP2A6NFE2L2L3MBTL1RELA | |
| SCHEMBL11209703 | 0.77 | MAOB (0.47) | ALDH1A1MAOBTSHRLMNAAKR1C3 | |
| SCHEMBL4029279 | 0.73 | ALDH1A1 (0.48) | ALDH1A1CYP2A6CYP19A1 | |
| SCHEMBL2659453 | 0.73 | RELA (0.35) | ALDH1A1MAOBTSHRCYP2A6LMNA | |
| SCHEMBL43963 | 0.73 | ALDH1A1 (0.33) | ALDH1A1MAOBTSHRCYP2A6LMNA | |
| SCHEMBL3218228 | 0.73 | ALDH1A1 (0.33) | ALDH1A1MAOBTSHRCYP2A6LMNA | |
| SCHEMBL2775035 | 0.72 | — | — | |
| SCHEMBL4781721 | 0.72 | APP (0.52) | ALDH1A1MAOBTSHRCYP2A6LMNA | |
| SCHEMBL3218909 | 0.70 | TLR8 (0.36) | ALDH1A1MAOBTSHRCYP2A6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2786985-A2 | Antagonists of the glucagon receptor | Metabasis Therapeutics, Inc. (US) | 2014-10-08 | — | — | EP | claimed |
| EP-2129654-A1 | NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR | Metabasis Therapeutics, Inc. (US) | 2009-12-09 | — | — | EP | claimed |
| WO-2008098244-A1 | NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR | METABASIS THERAPEUTICS, INC. (US) | 2008-08-14 | — | — | WO | claimed |
| US-7045529-B2 | Imidazopyrimidinyl and imidazopyri dinyl derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-05-16 | — | — | US | claimed |
| US-20040229887-A1 | Novel imidazopyrimidinyl and imidazopyri dinyl derivatives | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-11-18 | — | — | US | claimed |
| WO-2024014282-A1 | METHOD FOR PRODUCING TRIAZOLE DERIVATIVE ENANTIOMER (R) | 株式会社クレハ | 2024-01-18 | — | — | WO | disclosed |
| CN-113727606-B | Agricultural/horticultural fungicide, method for controlling plant disease, and product for controlling plant disease | 株式会社吴羽 | 2023-08-15 | — | — | CN | disclosed |
| EP-3712135-B1 | AZOLE DERIVATIVE, INTERMEDIATE COMPOUND, METHOD FOR PRODUCING AZOLE DERIVATIVE, AGENT FOR AGRICULTURAL AND HORTICULTURAL USE, AND MATERIAL PROTECTION AGENT FOR INDUSTRIAL USE | KUREHA CORP (JP) | 2023-05-03 | — | — | EP | disclosed |
| US-20220217978-A1 | BACTERICIDAL AGENT FOR AGRICULTURAL OR HORTICULTURAL USE, PLANT DISEASE CONTROL METHOD, AND PRODUCT FOR PLANT DISEASE CONTROL USE | KUREHA CORPORATION (JP) | 2022-07-14 | — | — | US | disclosed |
| EP-3957177-A1 | BACTERICIDAL AGENT FOR AGRICULTURAL OR HORTICULTURAL USE, PLANT DISEASE CONTROL METHOD, AND PRODUCT FOR PLANT DISEASE CONTROL USE | Kureha Corporation (JP) | 2022-02-23 | — | — | EP | disclosed |
| CN-113727606-A | Agricultural and horticultural bactericide, method for controlling plant disease, and product for controlling plant disease | 株式会社吴羽 | 2021-11-30 | — | — | CN | disclosed |
| CN-111032631-B | Azole derivative, intermediate compound, process for producing azole derivative, agricultural and horticultural chemical, and industrial material protective agent | 株式会社吴羽 | 2021-05-07 | — | — | CN | disclosed |
| WO-2008098244-A1 | NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR | METABASIS THERAPEUTICS, INC. (US) | 2008-08-14 | — | — | WO | disclosed |
| US-7045529-B2 | Imidazopyrimidinyl and imidazopyri dinyl derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-05-16 | — | — | US | disclosed |
| US-20040229887-A1 | Novel imidazopyrimidinyl and imidazopyri dinyl derivatives | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-11-18 | — | — | US | disclosed |
| EP-1244666-A1 | IMIDAZOPYRIMIDINYL AND IMIDAZOPYRIDINYL DERIVATIVES | Bristol-Myers Squibb Pharma Company (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001044248-A1 | IMIDAZOPYRIMIDINYL AND IMIDAZOPYRIDINYL DERIVATIVES | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-06-21 | — | — | WO | disclosed |
| WO-2000066588-A1 | DIRECT C-14 OXIDATION OF OPIOIDS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENTOF HEALTH A ND HUMAN SERVICES (US) | 2000-11-09 | — | — | WO | disclosed |
| EP-0532528-A1 | DERIVATIVES OF HYDROXY AND ALKOXY PYRIDINES | PFIZER INC. (US) | 1993-03-24 | — | — | EP | disclosed |
| WO-1991018881-A1 | DERIVATIVES OF HYDROXY AND ALKOXY PYRIDINES | PFIZER INC. (US) | 1991-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229887-A1 | Novel imidazopyrimidinyl and imidazopyri dinyl derivatives | CRH, GPR119, CRHR1 | ALDH1A1 2432/4885MAOB 2338/4885TSHR 567/4885 |
| US-20220217978-A1 | BACTERICIDAL AGENT FOR AGRICULTURAL OR HORTICULTURAL USE, PLANT DISEASE CONTROL METHOD, AND PRODUCT FOR PLANT DISEASE CONTROL USE | BROX, MGAM, CYP51A1 | ALDH1A1 2202/4885MAOB 1135/4885TSHR 3139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.