Sugi Predict

Sugi Predict / Compounds / SCHEMBL2659709

SCHEMBL2659709

SCHEMBL2659709

Brc1ccccc1-n1cncn1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.43
▸ CYP2A6 P11509 1/20 0.43
▸ ALDH1A1 P00352 3/20 0.39
▸ KDM4E B2RXH2 2/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ MGLL Q99685 1/20 0.38
▸ ACHE P22303 1/20 0.38
▸ MAPT P10636 2/20 0.37
▸ CYP19A1 P11511 2/20 0.36
▸ CRHBP P24387 1/20 0.36
▸ CRHR2 Q13324 1/20 0.36
▸ MEN1 O00255 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ POLB P06746 1/20 0.35
▸ HCRTR1 O43613 1/20 0.35
▸ HCRTR2 O43614 1/20 0.35
▸ HCAR1 Q9BXC0 1/20 0.35
▸ CYP1A2 P05177 2/20 0.35
▸ CYP2C9 P11712 2/20 0.35
▸ CYP2C19 P33261 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31521796 0.82 CYP2A6 (0.39) LMNACYP2A6ALDH1A1KDM4ESMN1; SMN2
SCHEMBL5537234 0.80 ALDH1A1 (0.43) LMNACYP2A6ALDH1A1KDM4ESMN1; SMN2
SCHEMBL4463697 0.76 LMNA (0.50) LMNACYP2A6ALDH1A1KDM4ESMN1; SMN2
SCHEMBL21893412 0.76 LMNA (0.43) LMNACYP2A6ALDH1A1KDM4ESMN1; SMN2
SCHEMBL6656755 0.76 CYP1A2 (0.48) LMNACYP2A6ALDH1A1KDM4ESMN1; SMN2
SCHEMBL5537238 0.76 IDO1 (0.47) LMNACYP2A6ALDH1A1KDM4ESMN1; SMN2
SCHEMBL1485032 0.76 CRHBP (0.48) LMNACYP2A6ALDH1A1KDM4ESMN1; SMN2
SCHEMBL2917479 0.76 LMNA (0.43) LMNACYP2A6ALDH1A1KDM4ESMN1; SMN2
SCHEMBL2463773 0.76 LMNA (0.43) LMNACYP2A6ALDH1A1KDM4ESMN1; SMN2
SCHEMBL29984835 0.76 CYP1A2 (0.48) LMNACYP2A6ALDH1A1KDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106165684-B Pesticidal compositions and methods relating thereto 陶氏益农公司 2019-06-14 — — CN disclosed
EP-3491922-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO Dow AgroSciences LLC (US) 2019-06-05 — — EP disclosed
CN-105025715-B Pesticidal compositions and methods related thereto 美国陶氏益农公司 2018-11-16 — — CN disclosed
CN-104981160-B Pesticidal compositions and methods related thereto 美国陶氏益农公司 2018-04-20 — — CN disclosed
EP-2934135-B1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2018-01-31 — — EP disclosed
EP-2934118-B1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2018-01-31 — — EP disclosed
EP-2934142-B1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2018-01-31 — — EP disclosed
CN-104981154-B Pesticidal compositions and methods related thereto 美国陶氏益农公司 2018-01-26 — — CN disclosed
US-20170267629-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2017-09-21 — — US disclosed
US-9701620-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES LLC (US) 2017-07-11 — — US disclosed
US-20140171310-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2014-06-19 — — US disclosed
US-20140171308-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2014-06-19 — — US disclosed
EP-2723729-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO Dow AgroSciences LLC (US) 2014-04-30 — — EP disclosed
CN-103748089-A Pesticidal compositions and methods relating thereto DOW AGROSCIENCES LLC 2014-04-23 — — CN disclosed
WO-2012177813-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2012-12-27 — — WO disclosed
US-20120329649-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC 2012-12-27 — — US disclosed
US-6642229-B2 Treatment of adverse neurological conditions MERCK SHARP & DOHME LTD. 2003-11-04 — — US disclosed
US-20030176449-A1 3-Phenyl-imidazo-pyrimidine derivatives as ligands for gaba receptors APPLIED MEDICAL RESOURCES CORPORATION 2003-09-18 — — US disclosed
EP-1294723-A1 3-PHENYL-IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS MERCK SHARP & DOHME LTD. (GB) 2003-03-26 — — EP disclosed
WO-2001090108-A1 3-PHENYL-IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS MERCK SHARP & DOHME LIMITED (GB) 2001-11-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170267629-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS LMNA 2825/4885CYP2A6 354/4885ALDH1A1 854/4885
US-20140171310-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS LMNA 2825/4885CYP2A6 354/4885ALDH1A1 854/4885
US-20120329649-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS LMNA 2825/4885CYP2A6 354/4885ALDH1A1 854/4885
US-20030176449-A1 3-Phenyl-imidazo-pyrimidine derivatives as ligands for gaba receptors GABRA3, GABBR2, GABRA2 LMNA 3231/4885CYP2A6 191/4885ALDH1A1 625/4885
US-20140171308-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS LMNA 2825/4885CYP2A6 354/4885ALDH1A1 854/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.