Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGALS8 | O00214 | 1/20 | 0.33 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 9/20 | 0.32 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.30 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2661758 | 0.90 | LGALS8 (0.32) | LGALS8LGALS3HDAC1HDAC3MCL1 | |
| SCHEMBL2659767 | 0.89 | PYGL (0.32) | LGALS8LGALS3MCL1HDAC2KMT2A | |
| SCHEMBL2660563 | 0.87 | HDAC3 (0.36) | HDAC1HDAC3 | |
| SCHEMBL2659802 | 0.86 | CTSS (0.32) | MCL1KDM4E | |
| SCHEMBL2660852 | 0.83 | PLA2G7 (0.33) | MCL1KMT2A | |
| SCHEMBL2660397 | 0.82 | MCL1 (0.31) | LGALS8LGALS3MCL1 | |
| SCHEMBL2659681 | 0.80 | SLC40A1 (0.37) | LGALS8LGALS3MCL1SLC40A1KDM4E | |
| SCHEMBL2660539 | 0.79 | MMP13 (0.40) | LGALS8LGALS3SLC40A1KDM4EGAA | |
| SCHEMBL2661002 | 0.79 | LGALS8 (0.32) | LGALS8LGALS3KDM4EKMT2A | |
| SCHEMBL2659988 | 0.79 | NAMPT (0.34) | HDAC1HDAC3HDAC2NAMPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074119-A1 | INDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |