Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 4/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | CCR1 | P32246 | 2/20 | 0.54 |
| ▸ | CCR5 | P51681 | 2/20 | 0.54 |
| ▸ | CCR8 | P51685 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | METAP1 | P53582 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.54 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.54 |
| ▸ | MIF | P14174 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31659392 | 1.00 | FLT3 (0.58) | FLT3GSK3BKDM4ELMNACCR1 | |
| SCHEMBL15293913 | 0.79 | KDM4E (0.44) | FLT3GSK3BKDM4ELMNACCR1 | |
| SCHEMBL17084697 | 0.78 | KDM4E (0.46) | FLT3GSK3BKDM4EKDM4AKDM5C | |
| SCHEMBL12075527 | 0.78 | BRD4 (0.41) | FLT3GSK3BKDM4ELMNACCR1 | |
| SCHEMBL15451914 | 0.78 | L3MBTL1 (0.57) | FLT3GSK3BKDM4ELMNACCR1 | |
| SCHEMBL13036564 | 0.77 | FLT3 (0.54) | FLT3GSK3BKDM4ELMNACCR1 | |
| SCHEMBL17108202 | 0.77 | FLT3 (0.54) | FLT3GSK3BKDM4ELMNACCR1 | |
| SCHEMBL13073931 | 0.77 | L3MBTL1 (0.60) | FLT3GSK3BKDM4ELMNACCR1 | |
| Dipyridyl SCHEMBL3796795 | 0.76 | KDM4E (0.93) | FLT3GSK3BKDM4ELMNACCR1 | |
| Dipyridyl SCHEMBL722577 | 0.76 | KDM4E (0.93) | FLT3GSK3BKDM4ELMNACCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10377745-B2 | Heterocyclic compounds as NaV channel inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2019-08-13 | — | — | US | disclosed |
| WO-2019077223-A1 | HEAT-SENSITIVE COPOLYMERS CAPABLE OF COMPLEXING CO(II) CATIONS IN AN AQUEOUS SOLUTION | ONET TECHNOLOGIES ND (FR) | 2019-04-25 | — | — | WO | disclosed |
| EP-2678346-B9 | METAL COMPLEXES FOR USE AS DOPANTS AND OTHER USES | ECOLE POLYTECHNIQUE FED LAUSANNE EPFL (CH) | 2018-08-08 | — | — | EP | disclosed |
| US-10038150-B2 | Metal complexes for use as dopants and other uses | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2018-07-31 | — | — | US | disclosed |
| EP-2678346-B1 | METAL COMPLEXES FOR USE AS DOPANTS AND OTHER USES | ECOLE POLYTECHNIQUE FED LAUSANNE EPFL (CH) | 2018-04-04 | — | — | EP | disclosed |
| US-9779879-B2 | Redox couple for electrochemical and optoelectronic devices | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2017-10-03 | — | — | US | disclosed |
| US-20170233377-A1 | HETEROCYCLIC COMPOUNDS AS NAV CHANNEL INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-08-17 | — | — | US | disclosed |
| US-9676757-B2 | Heterocyclic compounds as NaV channel inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2017-06-13 | — | — | US | disclosed |
| US-9559321-B2 | Metal complexes for use as dopants and other uses | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2017-01-31 | — | — | US | disclosed |
| US-20160233439-A1 | METAL COMPLEXES FOR USE AS DOPANTS AND OTHER USES | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) EPFL-TTO (CH) | 2016-08-11 | — | — | US | disclosed |
| US-20140060641-A1 | REDOX COUPLE FOR ELECTROCHEMICAL AND OPTOELECTRONIC DEVICES | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (FR) | 2014-03-06 | — | — | US | disclosed |
| EP-2638035-A1 | TRIAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-09-18 | — | — | EP | disclosed |
| EP-2551949-A1 | Metal complexes for use as dopants and other uses | Ecole Polytechnique Fédérale de Lausanne (EPFL) (CH) | 2013-01-30 | — | — | EP | disclosed |
| EP-2492277-A1 | Improved redox couple for electrochemical and optoelectronic devices | Ecole Polytechnique Fédérale de Lausanne (EPFL) (CH) | 2012-08-29 | — | — | EP | disclosed |
| WO-2012062623-A1 | TRIAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-05-18 | — | — | WO | disclosed |
| US-20120115868-A1 | NOVEL TRIAZOLE COMPOUNDS II | ROCHE PALO ALTO LLC | 2012-05-10 | — | — | US | disclosed |
| US-20110187265-A1 | PHOSPHORESCENT METAL COMPLEX COMPOUND, METHOD FOR THE PREPARATION THEREOF AND RADIATING COMPONENT | OSRAM OLED GMBH (DE) | 2011-08-04 | — | — | US | disclosed |
| US-20080262070-A1 | Pharmaceutically Active Tetrahydro-Pyrrolizinone Compounds | BAUMANN KARL | 2008-10-23 | — | — | US | disclosed |
| US-20080262070-A1 | Pharmaceutically Active Tetrahydro-Pyrrolizinone Compounds | BAUMANN KARL | 2008-10-23 | — | — | US | disclosed |
| WO-2007039286-A1 | TETRAHYDRO-PYRROLIZINONE COMPOUNDS AS LFA-I MEDIATORS | NOVARTIS AG (CH) | 2007-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170233377-A1 | HETEROCYCLIC COMPOUNDS AS NAV CHANNEL INHIBITORS AND USES THEREOF | CACNA1B, CACNG6, SCN5A | FLT3 3928/4885GSK3B 1336/4885KDM4E 2066/4885 |
| US-10038150-B2 | Metal complexes for use as dopants and other uses | SOD1, DDT, SOD3 | FLT3 3786/4885GSK3B 2872/4885KDM4E 4298/4885 |
| US-20120115868-A1 | NOVEL TRIAZOLE COMPOUNDS II | GABRA5, GABRA1, GABRA3 | FLT3 460/4885GSK3B 1176/4885KDM4E 1548/4885 |
| US-20160233439-A1 | METAL COMPLEXES FOR USE AS DOPANTS AND OTHER USES | SOD1, DDT, SOD3 | FLT3 3786/4885GSK3B 2872/4885KDM4E 4298/4885 |
| US-20080262070-A1 | Pharmaceutically Active Tetrahydro-Pyrrolizinone Compounds | VCAM1, ICAM1, EPCAM | FLT3 576/4885GSK3B 2391/4885KDM4E 3500/4885 |
| US-10377745-B2 | Heterocyclic compounds as NaV channel inhibitors and uses thereof | CACNA1B, CACNG6, SCN5A | FLT3 3928/4885GSK3B 1336/4885KDM4E 2066/4885 |
| US-20110187265-A1 | PHOSPHORESCENT METAL COMPLEX COMPOUND, METHOD FOR THE PREPARATION THEREOF AND RADIATING COMPONENT | OSTC, ORC3, OSBP | FLT3 1378/4885GSK3B 1142/4885KDM4E 3709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.