SCHEMBL2707618

SCHEMBL2707618

Cc1ccc(OC(F)(F)C(F)F)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 3/20 0.45
ACHE P22303 3/20 0.42
ALDH1A1 P00352 3/20 0.42
TSHR P16473 2/20 0.42
HSD17B10 Q99714 1/20 0.42
ABL1 P00519 1/20 0.41
BCR P11274 1/20 0.41
CETP P11597 2/20 0.40
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
NPSR1 Q6W5P4 1/20 0.39
BCHE P06276 1/20 0.38
SCN9A Q15858 1/20 0.38
GPR3 P46089 1/20 0.37
CYP3A4 P08684 1/20 0.37
TEAD4 Q15561 1/20 0.37
POLB P06746 2/20 0.36
TDP1 Q9NUW8 2/20 0.36
GAA P10253 1/20 0.36
TP53 P04637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1907911 0.88 ALDH1A1 (0.48) TRPV1ALDH1A1TSHRHSD17B10CETP
SCHEMBL17125350 0.87 ALDH1A1 (0.40) TRPV1ACHEALDH1A1TSHRHSD17B10
SCHEMBL10204487 0.85 LMNA (0.42) TRPV1ACHEALDH1A1TSHRHSD17B10
SCHEMBL10996501 0.83 ACHE (0.39) TRPV1ACHEALDH1A1TSHRHSD17B10
SCHEMBL12403373 0.82 CA1 (0.50) TRPV1ACHEALDH1A1TSHRHSD17B10
SCHEMBL29023648 0.80 TSHR (0.46) TRPV1ACHEALDH1A1TSHRHSD17B10
SCHEMBL4456125 0.79 ALDH1A1 (0.43) TRPV1ALDH1A1TSHRHSD17B10CETP
SCHEMBL5018754 0.78 ALDH1A1 (0.53) TRPV1ALDH1A1TSHRHSD17B10CETP
SCHEMBL12247710 0.78 TRPV1 (0.67) TRPV1ALDH1A1TSHRHSD17B10TDP1
SCHEMBL91415 0.78 GPR3 (0.53) ACHEALDH1A1TSHRBCHEGPR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024114190-A1 ELECTROLYTE COMPOSITION, METHOD FOR SECONDARY ELECTROLYTE FILLING, AND LITHIUM SECONDARY BATTERY 九江天赐高新材料有限公司 2024-06-06 WO claimed
WO-2024114190-A1 ELECTROLYTE COMPOSITION, METHOD FOR SECONDARY ELECTROLYTE FILLING, AND LITHIUM SECONDARY BATTERY 九江天赐高新材料有限公司 2024-06-06 WO disclosed
EP-1389216-B1 AVERMECTINS SUBSTITUTED IN THE 4\"-POSITION HAVING PESTICIDAL PROPERTIES MERIAL INC (US) 2017-02-22 EP disclosed
US-9321735-B2 Insecticidal triazines and pyrimidines Vestaron Corporation (US) 2016-04-26 US disclosed
US-9321735-B2 Insecticidal triazines and pyrimidines Vestaron Corporation (US) 2016-04-26 US disclosed
US-20150274674-A1 PYRAZOLE OR TRIAZOLE COMPOUNDS AND THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING SOMATIC MUTATION-RELATED DISEASES PTC THERAPEUTICS, INC. (US) 2015-10-01 US disclosed
US-9102599-B2 N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases BRISTOL-MYERS SQUIBB COMPANY (US) 2015-08-11 US disclosed
US-8785630-B2 Insecticidal triazines and pyrimidines Vestaron Corporation (US) 2014-07-22 US disclosed
US-8785630-B2 Insecticidal triazines and pyrimidines Vestaron Corporation (US) 2014-07-22 US disclosed
US-20130267705-A1 Insecticidal Triazines and Pyrimidines Vestaron Corporation (US) 2013-10-10 US disclosed
US-5196140-A ELECTRO-OPTICAL LIQUID CRYSTAL DISPLAY ELEMENT MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1993-03-23 US disclosed
EP-0313604-B1 ELECTRO-OPTICAL LIQUID CRYSTAL DISPLAY ELEMENT MERCK PATENT GmbH (DE) 1992-03-25 EP disclosed
US-4886516-A Diaminotetrafluoroethoxybenzenes, process for producing same and hair coloring agents containing same WELLA AKTIENGESELLSCHAFT (DE) 1989-12-12 US disclosed
US-4845294-A COUPLERS IN OXIDATIVE HAIR COLORING AGENTS WELLA AKTIENGESELLSCHAFT (DE) 1989-07-04 US disclosed
US-4199595-A M-phenoxybenzyl and α-cyano-M-phenoxybenzyl esters of 2-haloalkyl (oxy-, thio-, sulfinyl-, or sulfonyl)phenylalkanoic acids AMERICAN CYANAMID COMPANY (US) 1980-04-22 US disclosed
US-4199481-A ODORLESS EXTENDERS INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1980-04-22 US disclosed
US-4178460-A INTERMEDIATES FOR INSECTICIDES AMERICAN CYANAMID CO. (US) 1979-12-11 US disclosed
US-4170576-A Uses of mixtures of alpha methyl styrene dimers and terpene dimers in perfumery processes and products International Flavors & Fragrances Inc. (US) 1979-10-09 US disclosed
US-4165301-A Uses of terpene dimers in perfumery processes and products INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1979-08-21 US disclosed
US-4142998-A EXTENDERS INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1979-03-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130267705-A1 Insecticidal Triazines and Pyrimidines TYMS, TYMP, DHX15 TRPV1 1614/4885ACHE 52/4885ALDH1A1 3089/4885
US-20150274674-A1 PYRAZOLE OR TRIAZOLE COMPOUNDS AND THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING SOMATIC MUTATION-RELATED DISEASES UPF1, RNMT, VHL TRPV1 2344/4885ACHE 4777/4885ALDH1A1 2509/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.