Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5666359 | 0.78 | RAB9A (0.44) | ADRA2AADRA2BADRA2CHDAC6HSD17B10 | |
| SCHEMBL2760655 | 0.74 | ADRA2A (0.44) | ADRA2AADRA2BADRA2CHDAC1HDAC6 | |
| SCHEMBL676678 | 0.74 | HPGDS (0.56) | ADRA2AADRA2BADRA2CPTGS2HDAC1 | |
| SCHEMBL17051516 | 0.72 | HPGDS (0.54) | ADRA2AADRA2BADRA2CPTGS2HDAC1 | |
| SCHEMBL2714933 | 0.71 | GABRA1 (0.42) | CYP11B2ADRA2AADRA2BADRA2CPTGS2 | |
| SCHEMBL13505314 | 0.71 | ALDH1A1 (0.47) | ADRA2AADRA2BADRA2CATMTSHR | |
| SCHEMBL3346810 | 0.70 | MKNK1 (0.52) | CYP11B2PTGS2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL28051973 | 0.70 | GSK3B (0.52) | CYP11B2PTGS2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL1138580 | 0.69 | HSD17B1 (0.53) | HDAC1HDAC6MKNK1MKNK2IDO1 | |
| SCHEMBL29788311 | 0.69 | MKNK1 (0.58) | HDAC1HDAC6MKNK1MKNK2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445909-B1 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES | BOEHRINGER INGELHEIM INT (DE) | 2013-11-13 | — | — | EP | disclosed |
| EP-2445909-A1 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES | Boehringer Ingelheim International GmbH (DE) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010141273-A1 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-12-09 | — | — | WO | disclosed |