SCHEMBL2715544

SCHEMBL2715544

CC1=C(C)C(=O)C(Cc2cccnc2)=C(C)C1=O

nearest known ligand 0.75

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TBXAS1 P24557 5/20 0.75
POLB P06746 1/20 0.43
CHRNB2 P17787 3/20 0.43
CHRNA4 P43681 3/20 0.43
HRH4 Q9H3N8 1/20 0.42
HRH3 Q9Y5N1 1/20 0.42
NAPRT Q6XQN6 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2D6 P10635 1/20 0.42
CHRNA7 P36544 2/20 0.41
TDP1 Q9NUW8 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29747247 1.00 TBXAS1 (0.75) TBXAS1POLBCHRNB2CHRNA4HRH4
Hydrochloric Acid SCHEMBL594558 0.98 TBXAS1 (0.73) TBXAS1POLBCHRNB2CHRNA4HRH4
SCHEMBL24844947 0.86 TBXAS1 (1.00) TBXAS1TDP1L3MBTL1
SCHEMBL10728648 0.85 TBXAS1 (0.56) TBXAS1CHRNB2CHRNA4HRH4HRH3
SCHEMBL16067092 0.84 TBXAS1 (0.68) TBXAS1POLBCHRNB2CHRNA4HRH4
SCHEMBL3040732 0.78 TBXAS1 (0.50) TBXAS1CYP1A2TDP1L3MBTL1
SCHEMBL28772279 0.74 TBXAS1 (0.55) TBXAS1CHRNB2CHRNA4HRH4HRH3
SCHEMBL1658826 0.73 FES (0.61) POLBL3MBTL1
SCHEMBL727185 0.73 CYP1A2 (0.62) TBXAS1CHRNB2CHRNA4HRH4HRH3
SCHEMBL5780182 0.69 ALDH1A1 (0.59) TBXAS1CHRNB2CHRNA4L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 595 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2825208-B1 P75NTR NEUROTROPHIN BINDING PROTEIN FOR THERAPEUTIC USE LEVICEPT LTD (GB) 2017-05-17 EP claimed
US-20150037335-A1 THERAPEUTIC USE OF P75NTR NEUROTROPHIN BINDING PROTEIN LEVICEPT LTD (GB) 2015-02-05 US claimed
EP-2175728-B1 SODIUM CHANNEL INHIBITORS ICAGEN INC (US) 2014-09-10 EP claimed
CN-101146539-A Use of pde7 inhibitors for the treatment of neuropathic pain PFIZER LTD (GB) 2008-03-19 CN claimed
EP-1855686-A1 USE OF PDE7 INHIBITORS FOR THE TREATMENT OF NEUROPATHIC PAIN Pfizer Limited (GB) 2007-11-21 EP claimed
WO-2006092691-A1 USE OF PDE7 INHIBITORS FOR THE TREATMENT OF NEUROPATHIC PAIN PFIZER LIMITED (GB) 2006-09-08 WO claimed
EP-0234729-B1 QUINONE DERIVATIVES, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1991-12-27 EP claimed
JP-8169826-A None JP disclosed
US-20260146036-A1 CRYSTALLINE FORMS RAQUALIA PHARMA INC. (JP) 2026-05-28 US disclosed
US-20260139031-A1 FUSION PROTEIN LEVICEPT LTD (GB) 2026-05-21 US disclosed
EP-4377309-B1 CRYSTALLINE FORMS RAQUALIA PHARMA INC (JP) 2026-05-20 EP disclosed
US-20260115194-A1 NEW TREATMENTS FOR PAIN SEVENLESS THERAPEUTICS LTD (GB) 2026-04-30 US disclosed
EP-4720104-A1 LOW AFFINITY P75 NEUROTROPHIC RECEPTOR EXTRACELLULAR DOMAIN FUSED TO A FC MOIETY AS NGF ANTAGONIST THERAPY OF PAIN Levicept Limited (GB) 2026-04-08 EP disclosed
WO-2006011050-A2 PYRIDINE DERIVATIVES PFIZER LIMITED (GB) 2006-02-02 WO disclosed
US-6376528-B1 SYNERGISTIC MIXTURE G. D. SEARLE & CO. 2002-04-23 US disclosed
US-5563129-A Hydroquinone derivatives and intermediates for production thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-10-08 US disclosed
US-5534639-A Hydroquinone derivatives and intermediates for production thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-07-09 US disclosed
JP-H08169826-A PREVENTIVE AND THERAPEUTIC AGENT FOR CACHEXIA TAKEDA CHEM IND LTD 1996-07-02 JP disclosed
US-5436359-A Hydroquinone derivatives and intermediates for production thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-07-25 US disclosed
EP-0560568-A2 Hydroquinone derivatives and intermediates for production thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-09-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260146036-A1 CRYSTALLINE FORMS PRKCD, CCT8, CRYZ TBXAS1 3680/4885POLB 639/4885CHRNB2 1226/4885
US-20260115194-A1 NEW TREATMENTS FOR PAIN SOS1, OPRL1, SOS2 TBXAS1 2683/4885POLB 4752/4885CHRNB2 1090/4885
US-20260139031-A1 FUSION PROTEIN NTRK2, BDNF, NGFR TBXAS1 3549/4885POLB 3524/4885CHRNB2 105/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.