Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 4/20 | 0.39 |
| ▸ | NQO2 | P16083 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9738372 | 0.84 | NQO2 (0.46) | NQO1NQO2ALDH1A1KDM4E | |
| SCHEMBL9024667 | 0.82 | NQO1 (0.39) | NQO1NQO2LMNAPDCD1CD274 | |
| SCHEMBL3661083 | 0.81 | G6PD (0.34) | NQO1NQO2LMNAPDCD1CD274 | |
| SCHEMBL30613914 | 0.81 | G6PD (0.34) | NQO1NQO2LMNAPDCD1CD274 | |
| SCHEMBL9025023 | 0.80 | L3MBTL1 (0.50) | LMNAALDH1A1KDM4EMEN1GAA | |
| SCHEMBL9024487 | 0.78 | ABCB1 (0.42) | NQO1NQO2GLAALDH1A1KDM4E | |
| SCHEMBL9025088 | 0.77 | ALDH1A1 (0.40) | NQO1NQO2GLAALDH1A1KDM4E | |
| SCHEMBL9023847 | 0.75 | G6PD (0.39) | NQO1NQO2GLASCN8A | |
| SCHEMBL9024241 | 0.74 | MAPT (0.32) | PDCD1CD274 | |
| SCHEMBL9024575 | 0.73 | NQO2 (0.36) | NQO1NQO2GLASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021252316-A1 | GRANULAR COMPOSITION OF AN ERK INHIBITOR AND USES THEREOF | MERCK SHARP & DOHME CORP. (US) | 2021-12-16 | — | — | WO | disclosed |
| WO-2021087016-A1 | DOSING REGIMEN OF ANTI-CD27 ANTIBODIES FOR TREATMENT OF CANCER | MERCK SHARP & DOHME CORP. (US) | 2021-05-06 | — | — | WO | disclosed |
| EP-3525786-A1 | KDM5 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2019-08-21 | — | — | EP | disclosed |
| WO-2018071282-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |
| EP-3004395-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | Merck Sharp & Dohme Corp. (US) | 2016-04-13 | — | — | EP | disclosed |
| WO-2014197411-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | MERCK SHARP & DOHME CORP. (US) | 2014-12-11 | — | — | WO | disclosed |
| EP-2742043-A1 | PYRIDO-PYRIMIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2014-06-18 | — | — | EP | disclosed |
| WO-2013022519-A1 | PYRIDO-PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-02-14 | — | — | WO | disclosed |
| WO-2012161877-A1 | PYRIDINE-AND PYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-11-29 | — | — | WO | disclosed |
| EP-2515657-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-31 | — | — | EP | disclosed |
| WO-2012027239-A1 | NOVEL PYRAZOLO[1,5-a]PYRROLO[3,2-e]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |
| WO-2008090379-A1 | PYRAZOLOQUINAZOLINONES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2008-07-31 | — | — | WO | disclosed |