Sugi Predict

Sugi Predict / Compounds / SCHEMBL272773

SCHEMBL272773

SCHEMBL272773

Cc1ccc(-c2cnc(-c3ccccc3-c3ncc(-c4ccc(C)cc4)o3)o2)cc1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RAB9A P51151 11/20 0.73
▸ NPC1 O15118 10/20 0.73
▸ KMT2A Q03164 3/20 0.73
▸ GAA P10253 3/20 0.73
▸ HPGD P15428 8/20 0.63
▸ KDM4E B2RXH2 7/20 0.63
▸ ALDH1A1 P00352 7/20 0.63
▸ SMN1; SMN2 Q16637 6/20 0.63
▸ HSD17B10 Q99714 4/20 0.63
▸ MEN1 O00255 2/20 0.63
▸ TP53 P04637 2/20 0.63
▸ STAT1 P42224 1/20 0.63
▸ TSHR P16473 2/20 0.59
▸ ALOX15 P16050 1/20 0.59
▸ CASP1 P29466 1/20 0.59
▸ ATM Q13315 1/20 0.58
▸ MITF O75030 1/20 0.51
▸ PTPN1 P18031 4/20 0.50
▸ PTPN2 P17706 2/20 0.50
▸ PTPN6 P29350 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10910387 0.86 RAB9A (0.61) RAB9ANPC1KMT2AGAAHPGD
SCHEMBL5562081 0.86 ALOX15 (0.82) RAB9ANPC1KMT2AGAAHPGD
SCHEMBL4883303 0.86 ALOX15 (0.82) RAB9ANPC1KMT2AGAAHPGD
SCHEMBL8551557 0.85 RAB9A (0.60) RAB9ANPC1KMT2AGAAHPGD
SCHEMBL14585759 0.85 RAB9A (0.83) RAB9ANPC1KMT2AGAAHPGD
SCHEMBL14947177 0.85 RAB9A (0.83) RAB9ANPC1KMT2AGAAHPGD
SCHEMBL1471533 0.85 RAB9A (0.77) RAB9ANPC1KMT2AGAAHPGD
SCHEMBL17122220 0.83 RAB9A (0.80) RAB9ANPC1KMT2AGAAHPGD
SCHEMBL9604648 0.83 NPC1 (0.54) RAB9ANPC1KMT2AGAAHPGD
SCHEMBL3295181 0.81 RAB9A (0.72) RAB9ANPC1KMT2AGAAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8076072-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2011-12-13 — — US claimed
US-8026057-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2011-09-27 — — US claimed
US-7468243-B2 Nucleotide sequence labelling compoumd four use as tool in genetic engineering AFFYMETRIX, INC. (US) 2008-12-23 — — US claimed
US-7291463-B2 Incubating/condensating pseudoisocytidine molecule with (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride to provide a pseudouridine molecule; oncology diagnosis AFFYMETRIX, INC. (US) 2007-11-06 — — US claimed
US-20140187434-A1 Nucleic Acid Labeling Compounds AFFYMETRIX, INC. (US) 2014-07-03 — — US disclosed
US-8729251-B2 Parallel preparation of high fidelity probes in an array format AFFYMETRIX, INC. (US) 2014-05-20 — — US disclosed
US-20130197208-A1 Parallel Preparation of High Fidelity Probes in an Array Format AFFYMETRIX, INC. (US) 2013-08-01 — — US disclosed
US-8497064-B2 Nucleic acid labelling compounds AFFYMETRIX, INC. (US) 2013-07-30 — — US disclosed
US-8338585-B2 Parallel preparation of high fidelity probes in an array format AFFYMETRIX, INC. (US) 2012-12-25 — — US disclosed
US-8338093-B2 Primer array synthesis and validation AFFYMETRIX, INC. (US) 2012-12-25 — — US disclosed
US-8293684-B2 Locked nucleic acid reagents for labelling nucleic acids EXIQON (DK) 2012-10-23 — — US disclosed
US-20120184467-A1 Parallel Preparation of High Fidelity Probes in an Array Format AFFYMETRIX, INC. (US) 2012-07-19 — — US disclosed
US-20020182625-A1 Nucleotide sequence labelling compoumd four use as tool in genetic engineering AFFYMETRIX, INC. 2002-12-05 — — US disclosed
US-20020165372-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2002-11-07 — — US disclosed
WO-2002072779-A2 NUCLEIC ACID LABELING COMPOUNDS AFFYMETRIX, INC. (US) 2002-09-19 — — WO disclosed
WO-2000006771-A9 NUCLEIC ACID LABELING COMPOUNDS AFFYMETRIX INC (US) 2002-08-22 — — WO disclosed
US-20010044531-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2001-11-22 — — US disclosed
US-20010018514-A1 NUCLEIC ACID LABELING COMPOUNDS AFFYMETRIX, INC. 2001-08-30 — — US disclosed
EP-1124838-A2 NUCLEIC ACID LABELING COMPOUNDS Affymetrix, Inc. (US) 2001-08-22 — — EP disclosed
WO-2000006771-A2 NUCLEIC ACID LABELING COMPOUNDS AFFYMETRIX, INC. (US) 2000-02-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120184467-A1 Parallel Preparation of High Fidelity Probes in an Array Format POLM, POLRMT, RNGTT RAB9A 4621/4885NPC1 3493/4885KMT2A 2635/4885
US-20010044531-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL RAB9A 3593/4885NPC1 2835/4885KMT2A 1750/4885
US-20010018514-A1 NUCLEIC ACID LABELING COMPOUNDS RNGTT, DUT, FBL RAB9A 3593/4885NPC1 2835/4885KMT2A 1750/4885
US-20020165372-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL RAB9A 3593/4885NPC1 2835/4885KMT2A 1750/4885
US-20020182625-A1 Nucleotide sequence labelling compoumd four use as tool in genetic engineering RNGTT, POLM, RNMT RAB9A 3931/4885NPC1 2779/4885KMT2A 1760/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.