SCHEMBL27377899

SCHEMBL27377899

Nc1cc(-c2ccncc2)nc2[nH]ncc12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CLK1 P49759 1/20 0.44
▸ MAPT P10636 2/20 0.40
▸ ROCK2 O75116 3/20 0.39
▸ ACHE P22303 1/20 0.39
▸ PRKCB P05771 4/20 0.39
▸ PRKCA P17252 4/20 0.39
▸ PRKCH P24723 4/20 0.39
▸ PRKCE Q02156 4/20 0.39
▸ PRKCQ Q04759 4/20 0.39
▸ PRKCD Q05655 4/20 0.39
▸ ROCK1 Q13464 3/20 0.39
▸ PKN1 Q16512 2/20 0.39
▸ PKN2 Q16513 2/20 0.39
▸ PRKD1 Q15139 1/20 0.39
▸ PIK3CA P42336 2/20 0.39
▸ IDO1 P14902 1/20 0.39
▸ AKT1 P31749 1/20 0.39
▸ TLR8 Q9NR97 1/20 0.38
▸ LATS1 O95835 2/20 0.37
▸ ADORA2A P29274 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27377347 0.75 CLK1 (0.47) CLK1MAPTROCK2ROCK1PIK3CA
SCHEMBL29650635 0.72 LATS1 (0.56) ACHELATS1LATS2
SCHEMBL31706376 0.72 CHEK1 (0.45) MAPTROCK2ACHEROCK1IDO1
SCHEMBL23841035 0.69 NCF1 (0.43) MAPTROCK2ACHEROCK1IDO1
SCHEMBL24505991 0.69 ACHE (0.80) MAPTACHEADORA2AADORA1CYP1A2
SCHEMBL5048878 0.68 ACHE (0.53) MAPTACHELATS1ADORA2AADORA1
SCHEMBL5045730 0.68 ACHE (0.53) MAPTACHELATS1ADORA2AADORA1
SCHEMBL28603733 0.67 MAP2K3 (0.42) MAPTACHEPIK3CAADORA2AADORA1
SCHEMBL3055291 0.67 METAP2 (0.45) ADORA1GSK3B
SCHEMBL31591430 0.66 ALDH1A1 (0.55) MAPTADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260085062-A1 NOVEL COMPOUNDS AS CK2 INHIBITORS CAMBRIDGE ENTPR LTD (GB) 2026-03-26 — — US disclosed
EP-4584266-A1 NOVEL COMPOUNDS, COMPOSITIONS AND THERAPEUTIC USES THEREOF Cambridge Enterprise Limited (GB) 2025-07-16 — — EP disclosed
EP-4584249-A1 NOVEL COMPOUNDS AS CK2 INHIBITORS Cambridge Enterprise Limited (GB) 2025-07-16 — — EP disclosed
WO-2024052701-A1 NOVEL COMPOUNDS, COMPOSITIONS AND THERAPEUTIC USES THEREOF CAMBRIDGE ENTERPRISE LIMITED (GB) 2024-03-14 — — WO disclosed
WO-2024052701-A1 NOVEL COMPOUNDS, COMPOSITIONS AND THERAPEUTIC USES THEREOF CAMBRIDGE ENTERPRISE LIMITED (GB) 2024-03-14 — — WO disclosed
WO-2024052702-A1 NOVEL COMPOUNDS AS CK2 INHIBITORS CAMBRIDGE ENTERPRISE LIMITED (GB) 2024-03-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260085062-A1 NOVEL COMPOUNDS AS CK2 INHIBITORS CSNK1A1, CSNK1G1, CSNK2A3 CLK1 227/4885MAPT 1438/4885ROCK2 2190/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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