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Tryptophan

Tryptophan

SCHEMBL27434560

CC(C)C[C@H](N)C(=O)O.CC(C)[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)O.CSCC[C@H](N)C(=O)O.C[C@@H](O)[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](CO)C(=O)O.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O.N[C@@H](Cc1ccccc1)C(=O)O

nearest known ligand 0.49

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ GLP1R P43220 5/20 0.49
▸ GCGR P47871 1/20 0.49
▸ GIPR P48546 1/20 0.49
▸ CCKBR P32239 1/20 0.48
▸ PTH1R Q03431 8/20 0.48
▸ IL23R Q5VWK5 3/20 0.45
▸ GHSR Q92847 2/20 0.45
▸ NPY2R P49146 1/20 0.45
▸ KEAP1 Q14145 1/20 0.44
▸ RXFP1 Q9HBX9 1/20 0.44
▸ ECE1 P42892 1/20 0.44
▸ MUS81 Q96NY9 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tryptophan SCHEMBL26967547 0.92 GLP1R (0.49) GLP1RGCGRCCKBR
Tryptophan SCHEMBL27531779 0.92 GLP1R (0.49) GLP1RGCGRCCKBR
Tryptophan SCHEMBL27700398 0.90 GLP1R (0.46) GLP1RGCGRCCKBR
Tryptophan SCHEMBL27849549 0.89 GLP1R (0.46) GLP1RGCGRCCKBR
Tryptophan SCHEMBL27668300 0.89 GLP1R (0.46) GLP1RGCGRCCKBRPTH1R
Tryptophan SCHEMBL29220361 0.88 KISS1R (0.47) GHSRNPY2R
Tryptophan SCHEMBL27501630 0.86 IL23R (0.45) GLP1RGCGRGIPRCCKBRIL23R
Tryptophan SCHEMBL27376884 0.86 PTH1R (0.42) GLP1RGCGRGIPRCCKBRPTH1R
Tryptophan SCHEMBL27432308 0.86 KEAP1 (0.43) GLP1RCCKBRPTH1RIL23RKEAP1
Tryptophan SCHEMBL27389650 0.85 TUBB4A (0.44) GLP1RGCGRGIPRPTH1RIL23R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1127497-C Benzo thiacycloheptatriene-1, 1-dioxide derivatives, process for their preparation, pharmaceutical compositions containing them and their use AVENTIS PHARMA GMBH (DE) 2003-11-12 — — CN disclosed
CN-1391558-A Substituted 1,3-diaryl-2-pyridine-2-yl-3-(pyridine-2-ylamino)-propanol derivatives, methods for their production, pharmaceutical compositions containing the same and their use AVENTIS PHARMA GMBH (DE) 2003-01-15 — — CN disclosed
CN-1321166-A Propanolamine derivs. linked with bile acid used for treating disorders of lipid metabolism AVENTIS PHARMA GMBH (DE) 2001-11-07 — — CN disclosed
CN-1305469-A Benzo thiacycloheptatriene-1, 1-dioxide derivatives, process for their preparation, pharmaceutical compositions containing them and their use AVENTIS PHARMA GMBH (DE) 2001-07-25 — — CN disclosed
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