Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of 1-Phenethylpiperidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 4/20 | 0.96 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.92 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.61 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.61 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | LTA4H | P09960 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.62 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1-Phenethylpiperidine SCHEMBL7524827 | 1.00 | SIGMAR1 (0.96) | SIGMAR1SLC6A3HRH3CYP1A2CYP3A4 | |
| 1-Phenethylpiperidine SCHEMBL11404041 | 1.00 | SIGMAR1 (0.96) | SIGMAR1SLC6A3HRH3CYP1A2CYP3A4 | |
| Water SCHEMBL3683452 | 0.98 | SLC6A3 (0.96) | SIGMAR1SLC6A3HRH3LTA4HL3MBTL1 | |
| SCHEMBL11589061 | 0.98 | SIGMAR1 (1.00) | SIGMAR1SLC6A3HRH3CYP1A2CYP3A4 | |
| SCHEMBL11922748 | 0.98 | SIGMAR1 (1.00) | SIGMAR1SLC6A3HRH3CYP1A2CYP3A4 | |
| 1-Phenethylpiperidine SCHEMBL4054824 | 0.98 | SIGMAR1 (1.00) | SIGMAR1SLC6A3HRH3CYP1A2CYP3A4 | |
| 1-Phenethylpiperidine SCHEMBL917609 | 0.98 | SIGMAR1 (1.00) | SIGMAR1SLC6A3HRH3CYP1A2CYP3A4 | |
| 1-Phenethylpiperidine SCHEMBL31229056 | 0.96 | SIGMAR1 (0.96) | SIGMAR1SLC6A3HRH3CYP1A2CYP3A4 | |
| 1-Phenethylpiperidine SCHEMBL11507835 | 0.96 | SIGMAR1 (0.96) | SIGMAR1SLC6A3HRH3CYP1A2CYP3A4 | |
| 1-Phenethylpiperidine SCHEMBL27138909 | 0.96 | SIGMAR1 (0.96) | SIGMAR1SLC6A3HRH3CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1113454-A | Epoxidation process and catalyst therefore | ARCO CHEM TECH (US) | 1995-12-20 | — | — | CN | disclosed |