Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9022771 | 0.91 | ALDH1A1 (0.53) | ALDH1A1TDP1TSHRCNR2POLB | |
| SCHEMBL2759026 | 0.84 | ALDH1A1 (0.46) | ALDH1A1TDP1TSHRADRA2AADRA2B | |
| SCHEMBL423456 | 0.84 | ADRA2A (0.43) | ALDH1A1TDP1ADRA2AADRA2BADRA2C | |
| SCHEMBL7637421 | 0.83 | MAPT (0.52) | ALDH1A1TDP1TSHRPOLBLMNA | |
| SCHEMBL9490421 | 0.81 | ALDH1A1 (0.43) | ALDH1A1TDP1TSHRLMNAKMT2A | |
| SCHEMBL4668959 | 0.77 | ALDH1A1 (0.42) | ALDH1A1TDP1TSHRCYP3A4MAPK1 | |
| SCHEMBL5021020 | 0.77 | CALM1 (0.48) | ALDH1A1TDP1TSHRCNR2LMNA | |
| SCHEMBL15315297 | 0.77 | ALDH1A1 (0.40) | ALDH1A1TDP1TSHRADRA2AADRA2B | |
| SCHEMBL484008 | 0.77 | TDP1 (0.40) | ALDH1A1TDP1TSHRADRA2APOLB | |
| SCHEMBL2759017 | 0.76 | KMT2A (0.59) | ALDH1A1TDP1TSHRCNR2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140296343-A1 | NON-PEPTIDE BDNF NEUROTROPHIN MIMETICS | PHARMATROPHIX, INC. | 2014-10-02 | — | — | US | disclosed |
| US-20140296343-A1 | NON-PEPTIDE BDNF NEUROTROPHIN MIMETICS | PHARMATROPHIX, INC. | 2014-10-02 | — | — | US | disclosed |
| US-20120004310-A1 | NON-PEPTIDE BDNF NEUROTROPHIN MIMETICS | PHARMATROPHIX, INC. | 2012-01-05 | — | — | US | disclosed |
| US-20120004310-A1 | NON-PEPTIDE BDNF NEUROTROPHIN MIMETICS | PHARMATROPHIX, INC. | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004310-A1 | NON-PEPTIDE BDNF NEUROTROPHIN MIMETICS | BDNF, NTRK2, NGF | ALDH1A1 4203/4885TDP1 1015/4885TSHR 199/4885 |
| US-20140296343-A1 | NON-PEPTIDE BDNF NEUROTROPHIN MIMETICS | BDNF, NTRK2, NGF | ALDH1A1 4203/4885TDP1 1015/4885TSHR 199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.