SCHEMBL2762278

SCHEMBL2762278

CC1=Cc2cc3c(c(-c4ccc(C(C)(C)C)cc4)c2C1)CCC3

nearest known ligand 0.35

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
FGF23 Q9GZV9 1/20 0.35
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
CES1 P23141 1/20 0.31
KDM4E B2RXH2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3698571 0.97 CES1 (0.33) FGF23MEN1KMT2ACES1KDM4E
SCHEMBL27171020 0.92 FGF23 (0.30) FGF23
SCHEMBL17180472 0.88 MEN1 (0.31) MEN1KMT2A
SCHEMBL29776024 0.83 BRD4 (0.35) MEN1KMT2ACES1KDM4E
SCHEMBL3693341 0.83 BRD4 (0.35) MEN1KMT2ACES1KDM4E
SCHEMBL22776383 0.82 FGF23 (0.32) FGF23MEN1KMT2AKDM4E
SCHEMBL29595700 0.82 FGF23 (0.32) FGF23MEN1KMT2AKDM4E
SCHEMBL27171026 0.81
SCHEMBL180041 0.81 FGF23 (0.31) FGF23
SCHEMBL4191656 0.81 TSHR (0.32) KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4271718-A1 POLYOLEFIN-BASED IONOMERS AND PRODUCTION THEREOF ExxonMobil Chemical Patents Inc. (US) 2023-11-08 EP disclosed
US-11807655-B2 Catalysts BOREALIS AG (AT) 2023-11-07 US disclosed
CN-116670188-A Polyolefin-based ionomers and preparation thereof 埃克森美孚化学专利公司 2023-08-29 CN disclosed
US-11702487-B2 Process for preparing propylene polymers BOREALIS AG (AT) 2023-07-18 US disclosed
CN-111902436-B Process for preparing propylene polymers 博里利斯股份公司 2023-06-30 CN disclosed
CN-112424241-B Catalyst 博里利斯股份公司 2023-06-06 CN disclosed
US-11643427-B2 Catalysts BOREALIS AG (AT) 2023-05-09 US disclosed
CN-112292406-B Olefin polymerization catalyst 博里利斯股份公司 2023-04-04 CN disclosed
US-11542346-B2 Catalysts for olefin polymerization BOREALIS AG (AT) 2023-01-03 US disclosed
US-20220363703-A1 CATALYSTS BOREALIS AG (AT) 2022-11-17 US disclosed
EP-3562831-A1 CATALYSTS Borealis AG (AT) 2019-11-06 EP disclosed
WO-2018122134-A1 CATALYSTS BOREALIS AG (AT) 2018-07-05 WO disclosed
US-7842764-B2 bridged metallocene with indacene ring substituted in position 4 by a phenyl moiety and in positions 5 and 6 by a condensed ring; higher yields and polymers having very high molecular weight BASELL POLIOLEFINE ITALIA S.R.L. (IT) 2010-11-30 US disclosed
EP-1692144-B1 ORGANOMETALLIC TRANSITION METAL COMPOUND, BISCYCLOPENTADIENYL LIGAND SYSTEM, CATALYST SYSTEM AND PREPARATION OF POLYOLEFINS BASELL POLYOLEFINE GMBH (DE) 2010-04-14 EP disclosed
US-20090062491-A1 Metallocene Compounds BASELL POLYOLEFINE GMBH (DE) 2009-03-05 US disclosed
US-7452949-B2 Organometallic transition metal compound, biscyclopentadienyl ligand system, catalyst system and preparation of polyolefins BASELL POLYOLEFINE GMBH (DE) 2008-11-18 US disclosed
EP-1858907-B1 METALLOCENE COMPOUNDS BASELL POLYOLEFINE GMBH (DE) 2008-10-15 EP disclosed
US-20070155919-A1 Organometallic transition metal compound, biscyclopentadienyl ligand system, catalyst system and preparation of polyolefins BASELL POLYOLEFINE GMBH (DE) 2007-07-05 US disclosed
EP-1692144-A2 ORGANOMETALLIC TRANSITION METAL COMPOUND, BISCYCLOPENTADIENYL LIGAND SYSTEM, CATALYST SYSTEM AND PREPARATION OF POLYOLEFINS Basell Polyolefine GmbH (DE) 2006-08-23 EP disclosed
WO-2005058916-A2 ORGANOMETALLIC TRANSITION METAL COMPOUND, BISCYCLOPENTADIENYL LIGAND SYSTEM, CATALYST SYSTEM AND PREPARATION OF POLYOLEFINS BASELL POLYOLEFINE GMBH (DE) 2005-06-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070155919-A1 Organometallic transition metal compound, biscyclopentadienyl ligand system, catalyst system and preparation of polyolefins SOD1, ORC3, OPRM1 FGF23 3991/4885MEN1 1044/4885KMT2A 3460/4885
US-11807655-B2 Catalysts SOD1, MT-CO2, MT-CO1 FGF23 699/4885MEN1 314/4885KMT2A 794/4885
US-20090062491-A1 Metallocene Compounds H1-10, SOD1, MT-CO3 FGF23 1811/4885MEN1 33/4885KMT2A 946/4885
US-11643427-B2 Catalysts MLX, HAX1, CHRM1 FGF23 685/4885MEN1 2318/4885KMT2A 1681/4885
US-11542346-B2 Catalysts for olefin polymerization PCBP1, PCNA, PIN1 FGF23 4866/4885MEN1 1388/4885KMT2A 3886/4885
US-20220363703-A1 CATALYSTS SOD1, MT-CO2, MT-CO1 FGF23 699/4885MEN1 314/4885KMT2A 794/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.