Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 8/20 | 0.52 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.51 |
| ▸ | FNTA | P49354 | 4/20 | 0.50 |
| ▸ | FNTB | P49356 | 4/20 | 0.50 |
| ▸ | PGGT1B | P53609 | 4/20 | 0.50 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.49 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.48 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.48 |
| ▸ | ITGAL | P20701 | 2/20 | 0.48 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL28629633 | 1.00 | REN (0.52) | RENACE2FNTAFNTBPGGT1B | |
| SCHEMBL21925037 | 0.99 | REN (0.53) | RENACE2FNTAFNTBPGGT1B | |
| SCHEMBL28066061 | 0.87 | REN (0.49) | RENACE2SLC15A2ITGB2ICAM1 | |
| SCHEMBL9829089 | 0.82 | OPRM1 (0.62) | — | |
| SCHEMBL9829021 | 0.82 | OPRM1 (0.62) | — | |
| SCHEMBL28410134 | 0.82 | SLC15A2 (0.58) | RENACE2FNTAFNTBPGGT1B | |
| Water SCHEMBL1433025 | 0.81 | OPRM1 (0.46) | — | |
| Water SCHEMBL28629638 | 0.81 | OPRM1 (0.46) | — | |
| Water SCHEMBL1433018 | 0.81 | OPRM1 (0.46) | — | |
| SCHEMBL6670986 | 0.81 | GPR139 (0.63) | CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119708206-A | Antioxidant peptide and ACE (angiotensin converting enzyme) inhibitory peptide derived from tuna, and preparation methods and application thereof | 中国水产科学研究院南海水产研究所 | 2025-03-28 | — | — | CN | disclosed |
| CN-119569819-A | Peptide, inhibitor, screening method and application | 上海市农业科学院 | 2025-03-07 | — | — | CN | disclosed |
| CN-119020443-A | Separation and purification method for oat ACE (angiotensin converting enzyme) inhibitory peptide prepared by enzymolysis method | 南京西麦大健康科技有限公司 | 2024-11-26 | — | — | CN | disclosed |
| CN-115974969-B | Peptide with ACE inhibitory activity derived from selenium-enriched oyster and application thereof in preparation of antihypertensive preparation | 北部湾大学 | 2024-08-23 | — | — | CN | disclosed |
| CN-115960166-B | Selenium-enriched peptide for reducing blood pressure and application thereof | 华南农业大学 | 2024-06-07 | — | — | CN | disclosed |
| CN-117904239-A | Spleen pancreas heart protein peptide | 刘爽 | 2024-04-19 | — | — | CN | disclosed |
| WO-2022242339-A1 | OLIGOPEPTIDE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 澳优乳业（中国）有限公司 | 2022-11-24 | — | — | WO | disclosed |
| CN-101421390-B | Lactobacillus helveticus strains without lactose fermentation | GERVAIS DANONE SA | 2013-03-06 | — | — | CN | disclosed |
| CN-101421390-A | Lactobacillus helveticus strains without lactose fermentation | GERVAIS DANONE SA (FR) | 2009-04-29 | — | — | CN | disclosed |