Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | S100A4 | P26447 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.43 |
| ▸ | TUBB | P07437 | 2/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.43 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.43 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.43 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.43 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3949987 | 0.93 | TUBB4A (0.47) | KDM4EALDH1A1KMT2AMEN1USP2 | |
| SCHEMBL2776025 | 0.89 | HSD17B1 (0.50) | KDM4EALDH1A1KMT2AMEN1TUBB4A | |
| SCHEMBL29420327 | 0.86 | KMT2A (0.56) | KDM4EALDH1A1KMT2AMEN1USP2 | |
| SCHEMBL354177 | 0.86 | KMT2A (0.56) | KDM4EALDH1A1KMT2AMEN1USP2 | |
| SCHEMBL29420326 | 0.86 | KMT2A (0.56) | KDM4EALDH1A1KMT2AMEN1USP2 | |
| SCHEMBL24362549 | 0.82 | HSD17B1 (0.47) | KDM4EALDH1A1KMT2AMEN1TUBB4A | |
| SCHEMBL1807630 | 0.82 | HSD17B1 (0.50) | KDM4EALDH1A1KMT2AMEN1TUBB4A | |
| SCHEMBL1561740 | 0.81 | HTR2A (0.51) | KDM4EALDH1A1KMT2AMEN1USP2 | |
| SCHEMBL606742 | 0.80 | PTGS2 (0.47) | KDM4EALDH1A1KMT2AMEN1USP2 | |
| SCHEMBL2494625 | 0.80 | MAPK10 (0.47) | KDM4EALDH1A1KMT2AMEN1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583738-B1 | INDENONCARBOXYLIC ACIDS DERIVATIVES AND THEIR USE FOR THE TREATMENT OF AND PREVENTING DIABETES AND DYSLIPIDAEMIA | MERCK PATENT GMBH (DE) | 2017-05-10 | — | — | EP | disclosed |
| EP-1966136-B1 | NOVEL PROCESS FOR PRODUCTION OF HIGHLY PURE POLYMORPH (I) DONEPEZIL HYDROCHLORIDE | RICHTER GEDEON NYRT (HU) | 2014-02-26 | — | — | EP | disclosed |
| US-7767667-B2 | Pesticidal heterocycles | FMC CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-20090012070-A1 | PESTICIDAL HETEROCYCLES | BAYER CROPSCIENCE AG (DE) | 2009-01-08 | — | — | US | disclosed |
| US-7417057-B2 | Pesticidal heterocycles | BAYER CROPSCIENCE AG (DE) | 2008-08-26 | — | — | US | disclosed |
| US-20060252762-A1 | Methods for treatment of multiple sclerosis | WHITEHEAD CLARK M | 2006-11-09 | — | — | US | disclosed |
| US-20060100210-A1 | Methods for treatment of scleroderma | WHITEHEAD CLARK M | 2006-05-11 | — | — | US | disclosed |
| EP-1499609-A4 | PESTICIDAL HETEROCYCLES | FMC CORP (US) | 2005-09-14 | — | — | EP | disclosed |
| US-20050143418-A1 | Pesticidal heterocycles | FMC CORPORATION | 2005-06-30 | — | — | US | disclosed |
| US-6906064-B2 | Method for treating a patient with neoplasia using Iressa | OSI PHARMACEUTICALS, INC. | 2005-06-14 | — | — | US | disclosed |
| US-20030009033-A1 | Substituted condensation products of N-benzyl-3-indenylacent amides with heterocyclic aldehydes for neoplasia | OSI PHARMACEUTICALS, INC. | 2003-01-09 | — | — | US | disclosed |
| US-6479493-B1 | INHIBITING PHOSPHODIESTERASE 2 IN THE DISEASED TISSUE, WITHOUT SUBSTANTIALLY INHIBITING CYCLOOXYGENASES I AND II, THEREBY CAUSING MACROPHAGE APOPTOSIS | CELL PATHWAYS, INC. | 2002-11-12 | — | — | US | disclosed |
| US-6465494-B1 | PHOSPHODIESTERASE 2 AND 5 INHIBITORS; DOES NOT SUBSTANTIALLY INHIBIT COX I OR II; INDUCING APOPTOSIS IN PULMONARY MACROPHAGES THAT GENERATE LUNG DAMAGING METABOLITES AND LEUKOTRIENE B4 | CELL PATHWAYS, INC. | 2002-10-15 | — | — | US | disclosed |
| US-6426349-B1 | ADMINISTERING (Z)-5-FLUORO-2-METHYL-(4-PYRIDYLIDENE)-3-(N-BENZYL) INDENYLACETAMIDE HYDROCHLORIDE; REGULATING APOPTOSIS | CELL PATHWAY AND THE UNIVERSITY OF ARIZONA | 2002-07-30 | — | — | US | disclosed |
| US-6166053-A | Substituted condensation products of N-benzyl-3-idenylacetamides with heterocyclic aldehydes for neoplasia | CELL PATHWAYS, INC. (US) | 2000-12-26 | — | — | US | disclosed |
| EP-1044187-A1 | N-BENZYL-3-INDENYLACETAMIDES DERIVATIVES FOR TREATING NEOPLASIA | OSI Pharmaceuticals, Inc. (US) | 2000-10-18 | — | — | EP | disclosed |
| US-6066634-A | PHOSPHODIESTERASE INHIBITOR | CELL PATHWAYS, INC. (US) | 2000-05-23 | — | — | US | disclosed |
| US-6028116-A | Substituted condensation products of 1H-indenyl-hydroxyalkanes with aldehydes for neoplasia | CELL PATHWAYS, INC. (US) | 2000-02-22 | — | — | US | disclosed |
| US-5948779-A | APOPTOSIS; ANTICANCER AGENT | CELL PATHWAYS, INC. (US) | 1999-09-07 | — | — | US | disclosed |
| WO-1999031065-A1 | N-BENZYL-3-INDENYLACETAMIDES DERIVATIVES FOR TREATING NEOPLASIA | CELL PATHWAYS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012070-A1 | PESTICIDAL HETEROCYCLES | DDT, CBR3, ACHE | KDM4E 3146/4885ALDH1A1 4036/4885KMT2A 3878/4885 |
| US-20030009033-A1 | Substituted condensation products of N-benzyl-3-indenylacent amides with heterocyclic aldehydes for neoplasia | ACIN1, AOX1, CCAR2 | KDM4E 4309/4885ALDH1A1 146/4885KMT2A 1774/4885 |
| US-20060100210-A1 | Methods for treatment of scleroderma | SSB, TST, ETF1 | KDM4E 1928/4885ALDH1A1 678/4885KMT2A 1907/4885 |
| US-20060252762-A1 | Methods for treatment of multiple sclerosis | MYT1, PMP22, OTC | KDM4E 1493/4885ALDH1A1 973/4885KMT2A 1165/4885 |
| US-20050143418-A1 | Pesticidal heterocycles | DDT, TRHR, ACHE | KDM4E 3256/4885ALDH1A1 3938/4885KMT2A 3837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.