Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Chromone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.51 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.43 |
| ▸ | PARP1 known ✓ | P09874 | 1/20 | 0.41 |
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.41 |
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 6/20 | 0.95 |
| ▸ | MAOB | P27338 | 6/20 | 0.95 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.95 |
| ▸ | GRM5 | P41594 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chromone SCHEMBL26661260 | 1.00 | MAOA (0.95) | MAOAMAOBFTOACHEGRM5 | |
| Chromone SCHEMBL30075941 | 0.98 | MAOA (1.00) | MAOAMAOBFTOACHEGRM5 | |
| Chromone SCHEMBL29369932 | 0.98 | MAOA (1.00) | MAOAMAOBFTOACHEGRM5 | |
| Chromone SCHEMBL6347379 | 0.98 | MAOA (1.00) | MAOAMAOBFTOACHEGRM5 | |
| Chromone SCHEMBL28268880 | 0.98 | MAOA (1.00) | MAOAMAOBFTOACHEGRM5 | |
| Chromone SCHEMBL37994 | 0.98 | MAOA (1.00) | MAOAMAOBFTOACHEGRM5 | |
| Chromone SCHEMBL1034108 | 0.95 | MAOA (0.95) | MAOAMAOBFTOACHEGRM5 | |
| Chromone SCHEMBL31277121 | 0.95 | MAOA (0.95) | MAOAMAOBFTOACHEGRM5 | |
| Chromone SCHEMBL31622445 | 0.95 | MAOA (0.95) | MAOAMAOBFTOACHEGRM5 | |
| Chromone SCHEMBL3203755 | 0.95 | MAOA (0.95) | MAOAMAOBFTOACHEGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115385884-A | Extraction and separation method of new chromone alcohols in purslane and application thereof | 辽宁中医药大学 | 2022-11-25 | — | — | CN | claimed |
| CN-106397445-A | Pyrazoles N-p-bromophenyl maleimide derivative containing chromone structure as well as preparation method and application thereof | 绍兴文理学院 | 2017-02-15 | — | — | CN | claimed |
| CN-105924445-A | Pyrazole-type N-p-nitrophenyl maleimide derivative containing chromone structure, and preparation method and application thereof | 绍兴文理学院 | 2016-09-07 | — | — | CN | claimed |
| CN-105906634-A | 3-(6-bromine-4-oxygen-4H-chromone)-1-phenyl-5-p-methoxyphenyl-1, 6a-pyrroline (3, 4-c) pyrazole-4, 6(3aH, 5H)-diketone and preparation method and application thereof | 绍兴文理学院 | 2016-08-31 | — | — | CN | claimed |
| CN-105906632-A | Pyrazole-type N-p-methylphenyl maleimide derivative with chromone structure, and preparation method and application thereof | 绍兴文理学院 | 2016-08-31 | — | — | CN | claimed |
| CN-105859724-A | 3-(6-bromo-4-oxy-4H-chromone)-1-phenyl-5-p-chlorphenyl-1,6a-dihydro pyrroline[3,4-c] pyrazole-4,6(3aH,5H)-diketone and preparation method and application thereof | 绍兴文理学院 | 2016-08-17 | — | — | CN | claimed |
| CN-115385884-B | Extraction and separation method of neochronol in purslane and application thereof | 辽宁中医药大学 | 2023-04-25 | — | — | CN | disclosed |
| CN-115716790-A | Extraction and separation method and application of amide ester alkaloid in purslane | 辽宁中医药大学 | 2023-02-28 | — | — | CN | disclosed |
| CN-115385884-A | Extraction and separation method of new chromone alcohols in purslane and application thereof | 辽宁中医药大学 | 2022-11-25 | — | — | CN | disclosed |
| CN-115385884-A | Extraction and separation method of new chromone alcohols in purslane and application thereof | 辽宁中医药大学 | 2022-11-25 | — | — | CN | disclosed |
| CN-112535282-A | Food for regulating diabetes | 深圳市华韵生物科技产业有限公司 | 2021-03-23 | — | — | CN | disclosed |
| CN-109700997-A | A kind of External-applicationtraditional traditional Chinese medicinal and preparation method thereof for set a broken bone section disease | 贵州苗老吉药业有限公司 | 2019-05-03 | — | — | CN | disclosed |
| CN-107955013-B | A kind of method of the preparation method of Benzofurantone compound hamaudol and detection wherein optical isomer | 南京美新诺医药科技有限公司 | 2019-02-15 | — | — | CN | disclosed |
| CN-104147147-A | Traditional Chinese medicinal composition for treating skin diseases and preparation method thereof | HENAN MINGXUAN FOOD TECHNOLOGY CO LTD | 2014-11-19 | — | — | CN | disclosed |
| CN-104127558-A | Heat-clearing and detoxifying traditional Chinese medicine composition for livestock, and preparation method and application thereof | HENAN JINERKANG ANIMAL PHARMACEUTICAL CO LTD | 2014-11-05 | — | — | CN | disclosed |
| CN-104107215-A | Medicinal composition for treating allergic rhinitis | PANG HAILING | 2014-10-22 | — | — | CN | disclosed |
| CN-103989763-A | Compound arthritis capsules for treating hemophilia joint diseases, and preparation method thereof | SHAANXI UNIVERSITY S INST OF HEMOPHILIA | 2014-08-20 | — | — | CN | disclosed |
| CN-103585452-A | Traditional Chinese medicinal composition for treating xerophthalmia | XIE LIKE | 2014-02-19 | — | — | CN | disclosed |
| CN-102488096-B | Natural plant feedstuff additive, preparation method thereof, and feedstuff | INST AGRI RESOURCES CAAS | 2013-04-10 | — | — | CN | disclosed |
| CN-102488096-A | Natural plant feedstuff additive, preparation method thereof, and feedstuff | INST AGRI RESOURCES CAAS | 2012-06-13 | — | — | CN | disclosed |