Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | CACNA1S | Q13698 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | RBP4 | P02753 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27883834 | 0.83 | AADAT (0.51) | NOTUMAADATGAAALDH1A1AGTR2 | |
| SCHEMBL27825462 | 0.81 | NOTUM (0.45) | NOTUMTTRCACNA1S | |
| SCHEMBL28800023 | 0.80 | LDHA (0.44) | NOTUMTTRGAARBP4AGTR2 | |
| SCHEMBL27867459 | 0.77 | AADAT (0.51) | NOTUMAADATGAAAGTR2 | |
| SCHEMBL27867457 | 0.77 | UCHL1 (0.37) | GSK3BAGTR2 | |
| SCHEMBL27883825 | 0.77 | AADAT (0.51) | NOTUMAADATGAAALDH1A1TDP1 | |
| SCHEMBL27867427 | 0.75 | UCHL1 (0.41) | AGTR2 | |
| SCHEMBL27883809 | 0.74 | ALK (0.36) | NOTUMTTR | |
| SCHEMBL2428200 | 0.70 | NOTUM (0.55) | NOTUMTTRAKR1C3CACNA1SHTR2C | |
| SCHEMBL1445011 | 0.69 | ACE (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102639497-A | Compounds inhibitors of enzyme lactate dehydrogenase (LDH) and pharmaceutical compositions containing these compounds | UNIV PISA | 2012-08-15 | — | — | CN | disclosed |