Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | FAAH | O00519 | 5/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 5/20 | 0.38 |
| ▸ | CES1 | P23141 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL3645976 | 0.89 | EPHX2 (0.55) | EPHX2TSHRFAAHRECQLGLA | |
| Acetic Acid SCHEMBL28730807 | 0.87 | EPHX2 (0.54) | EPHX2TSHRFAAHRECQLGLA | |
| Bicarbonate SCHEMBL28494347 | 0.85 | EPHX2 (0.55) | EPHX2TSHRFAAHRECQLGLA | |
| Acetic Acid SCHEMBL28201981 | 0.85 | EPHX2 (0.55) | EPHX2TSHRFAAHRECQLGLA | |
| Bicarbonate SCHEMBL5377762 | 0.85 | EPHX2 (0.55) | EPHX2TSHRFAAHRECQLGLA | |
| Acetic Acid SCHEMBL29141866 | 0.83 | EPHX2 (0.50) | EPHX2TSHRFAAHRECQLGLA | |
| Acetic Acid SCHEMBL27751674 | 0.83 | EPHX2 (0.54) | EPHX2TSHRFAAHRECQLGLA | |
| Methyl Alcohol SCHEMBL25250336 | 0.82 | EPHX2 (0.56) | EPHX2TSHRFAAHRECQLGLA | |
| Methyl Alcohol SCHEMBL284907 | 0.82 | EPHX2 (0.56) | EPHX2TSHRFAAHRECQLGLA | |
| Methyl Alcohol SCHEMBL10778854 | 0.82 | EPHX2 (0.56) | EPHX2TSHRFAAHRECQLGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102731702-B | Surface-sulfonated monodisperse P(MMA-BA-St) polymer latex nanoparticles and preparation method thereof | UNIV NORTHWESTERN POLYTECHNIC | 2014-05-14 | — | — | CN | disclosed |
| CN-102731702-A | Surface-sulfonated monodisperse P(MMA-BA-St) polymer latex nanoparticles and preparation method thereof | UNIV NORTHWESTERN POLYTECHNIC | 2012-10-17 | — | — | CN | disclosed |