Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.53 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | F7 | P08709 | 1/20 | 0.47 |
| ▸ | F3 | P13726 | 1/20 | 0.47 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24970247 | 0.87 | HTT (0.52) | HTTGAAALDH1A1APPHCAR3 | |
| SCHEMBL27670331 | 0.87 | HTT (0.55) | HTTGAAALDH1A1APPHCAR3 | |
| SCHEMBL9763463 | 0.85 | HTT (0.56) | HTTGAAALDH1A1APPHCAR3 | |
| SCHEMBL30476608 | 0.83 | HTT (0.63) | HTTGAAALDH1A1APPHCAR3 | |
| SCHEMBL2111661 | 0.83 | HTT (0.63) | HTTGAAALDH1A1APPHCAR3 | |
| Hydrochloric Acid SCHEMBL30055763 | 0.82 | HTT (0.61) | HTTGAAALDH1A1APPHCAR3 | |
| SCHEMBL27739216 | 0.82 | ALDH1A1 (0.55) | HTTGAAALDH1A1APPHCAR3 | |
| SCHEMBL9458366 | 0.81 | GAA (0.68) | HTTGAAALDH1A1APPHCAR3 | |
| SCHEMBL14855190 | 0.81 | HTT (0.61) | HTTGAAALDH1A1APPHCAR3 | |
| Hydrogen Peroxide SCHEMBL28248196 | 0.81 | ALDH1A1 (0.62) | HTTGAAALDH1A1APPHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230355550-A1 | KETAMINE COMPOUNDS AND PROCESSES FOR MAKING AND USING THEM | ALTER DOMUS (US) LLC | 2023-11-09 | — | — | US | disclosed |
| US-11753378-B2 | Ketamine compounds and processes for making and using them | ZEVRA THERAPEUTICS, INC. (US) | 2023-09-12 | — | — | US | disclosed |
| US-20220348544-A1 | KETAMINE COMPOUNDS AND PROCESSES FOR MAKING AND USING THEM | ALTER DOMUS (US) LLC | 2022-11-03 | — | — | US | disclosed |
| US-9511060-B2 | Non-flushing niacin analogues, and methods of use thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2016-12-06 | — | — | US | disclosed |
| US-20160151343-A1 | NON-FLUSHING NIACIN ANALOGUES, AND METHODS OF USE THEREOF | TRUSTEES OF TUFTS COLLEGE | 2016-06-02 | — | — | US | disclosed |
| EP-2054386-B1 | NON-FLUSHING NIACIN ANALOGUES, AND METHODS OF USE THEREOF | TUFTS COLLEGE (US) | 2014-10-08 | — | — | EP | disclosed |
| US-8377971-B2 | Non-flushing niacin analogues, and methods of use thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2013-02-19 | — | — | US | disclosed |
| US-20110065794-A1 | Wrinkle-preventing and improving composition | SHISEIDO COMPANY, LTD. (JP) | 2011-03-17 | — | — | US | disclosed |
| US-20100168468-A1 | WRINKLE-PREVENTING AND IMPROVING COMPOSITION | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-07-01 | — | — | US | disclosed |
| US-20090312355-A1 | Non-Flushing Niacin Analogues, and Methods of Use Thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2009-12-17 | — | — | US | disclosed |
| EP-1908454-A1 | WRINKLE-PREVENTIVE/AMELIORATING AGENT | SHISEIDO COMPANY, LTD. (JP) | 2008-04-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11753378-B2 | Ketamine compounds and processes for making and using them | OPRK1, GRIK3, GRIN3B | HTT 1021/4885GAA 2960/4885ALDH1A1 3239/4885 |
| US-20090312355-A1 | Non-Flushing Niacin Analogues, and Methods of Use Thereof | SLC33A1, CHLSN, APOB | HTT 49/4885GAA 2258/4885ALDH1A1 1689/4885 |
| US-20160151343-A1 | NON-FLUSHING NIACIN ANALOGUES, AND METHODS OF USE THEREOF | SLC33A1, CHLSN, APOB | HTT 49/4885GAA 2241/4885ALDH1A1 1680/4885 |
| US-20230355550-A1 | KETAMINE COMPOUNDS AND PROCESSES FOR MAKING AND USING THEM | OPRK1, GRIK3, GRIN3B | HTT 1021/4885GAA 2960/4885ALDH1A1 3239/4885 |
| US-20220348544-A1 | KETAMINE COMPOUNDS AND PROCESSES FOR MAKING AND USING THEM | OPRK1, GRIK3, GRIN3B | HTT 1021/4885GAA 2960/4885ALDH1A1 3239/4885 |
| US-20100168468-A1 | WRINKLE-PREVENTING AND IMPROVING COMPOSITION | COL1A1, COL2A1, COL14A1 | HTT 784/4885GAA 2177/4885ALDH1A1 2131/4885 |
| US-20110065794-A1 | Wrinkle-preventing and improving composition | COL1A1, COL2A1, COL14A1 | HTT 784/4885GAA 2177/4885ALDH1A1 2131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.