Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCEH1 | Q6PIU2 | 8/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16965115 | 0.86 | RAB9A (0.60) | NCEH1TSHRRAB9APKMNPC1 | |
| SCHEMBL16965297 | 0.80 | NCEH1 (0.54) | NCEH1TSHRRAB9APKMNPC1 | |
| SCHEMBL29728586 | 0.80 | NCEH1 (0.54) | NCEH1TSHRRAB9APKMNPC1 | |
| SCHEMBL19180363 | 0.79 | PKM (0.67) | NCEH1TSHRRAB9APKMNPC1 | |
| SCHEMBL9195644 | 0.78 | KDM4E (0.59) | TSHRSMN1; SMN2ALDH1A1ADRA2BPTGS1 | |
| O-Tolyl Dimethylcarbamate SCHEMBL8927621 | 0.78 | NCEH1 (0.56) | NCEH1TSHRRAB9APKMNPC1 | |
| SCHEMBL14467975 | 0.78 | NCEH1 (0.53) | NCEH1TSHRRAB9APKMNPC1 | |
| SCHEMBL362353 | 0.78 | PTGS2 (0.57) | TSHRLMNASMN1; SMN2ALDH1A1ADRA2B | |
| SCHEMBL16993632 | 0.77 | ACHE (0.45) | NCEH1TSHRBCHELMNASMN1; SMN2 | |
| SCHEMBL1362672 | 0.77 | ALDH1A1 (0.50) | TSHRLMNASMN1; SMN2ALDH1A1ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101565420-B | Limk2 inhibitors, compositions comprising them, and methods of their use | LEXICON PHARMACEUTICALS INC | 2015-05-20 | — | — | CN | disclosed |