SCHEMBL2804814

SCHEMBL2804814

Cc1cccc2cc(C(=O)O)c(C(=O)O)nc12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.45
LMNA P02545 2/20 0.45
HTT P42858 1/20 0.45
ALDH1A1 P00352 2/20 0.44
HPGD P15428 1/20 0.44
HSD17B10 Q99714 1/20 0.44
MAPT P10636 2/20 0.42
POLB P06746 1/20 0.42
CRHBP P24387 1/20 0.42
GFER P55789 1/20 0.42
CRHR2 Q13324 1/20 0.42
PDE3B Q13370 1/20 0.42
PDE3A Q14432 1/20 0.42
ATM Q13315 1/20 0.42
MYC P01106 2/20 0.41
MEN1 O00255 1/20 0.41
NPC1 O15118 1/20 0.41
GAA P10253 1/20 0.41
RAB9A P51151 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29111712 0.86 KDM4E (0.46) KDM4ELMNAHTTALDH1A1HPGD
SCHEMBL30708183 0.86 KDM4E (0.46) KDM4ELMNAHTTALDH1A1HPGD
SCHEMBL29058294 0.85 ALDH1A1 (0.52) KDM4ELMNAHTTALDH1A1HPGD
SCHEMBL28202043 0.84 ALDH1A1 (0.49) KDM4ELMNAALDH1A1HPGDHSD17B10
SCHEMBL28231534 0.82 MAPT (0.45) KDM4EALDH1A1HSD17B10MAPTPDE3B
SCHEMBL2312441 0.82 MAPT (0.51) KDM4EHTTMAPTPOLBMEN1
SCHEMBL5459806 0.81 ALDH1A1 (0.50) KDM4ELMNAHTTALDH1A1HPGD
SCHEMBL634256 0.80 SMN1; SMN2 (0.44) KDM4ELMNAHTTALDH1A1HPGD
SCHEMBL5785101 0.77 KDM4E (0.51) KDM4ELMNAHTTALDH1A1HPGD
SCHEMBL7564788 0.76 KDM4E (0.47) KDM4ELMNAHTTALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108546223-B Process for the manufacture of nitriles and their corresponding amines 中国石化扬子石油化工有限公司 2022-02-11 CN claimed
CN-108164381-B Process for the manufacture of nitriles and their corresponding amines 中国石化扬子石油化工有限公司 2022-02-11 CN claimed
CN-105016939-A Preparation methods of nitrile and corresponding amine SINOPEC YANGZI PETROCHEMICAL 2015-11-04 CN claimed
CN-105016940-A Process for the manufacture of nitriles and their corresponding amines SINOPEC YANGZI PETROCHEMICAL 2015-11-04 CN claimed
CN-105001032-A Process for the manufacture of nitriles and their corresponding amines SINOPEC YANGZI PETROCHEMICAL 2015-10-28 CN claimed
US-8968711-B2 Cosmetic or dermatological composition comprising a polymer bearing junction groups, and cosmetic treatment process L'OREAL (FR) 2015-03-03 US claimed
US-20100272660-A1 COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT L'OREAL (FR) 2010-10-28 US claimed
US-20100239509-A1 COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS L'OREAL (FR) 2010-09-23 US claimed
EP-4204100-A1 HAIR LIGHTENING COMPOSITIONS PROVIDING DAMAGE PROTECTION AND SENSORIAL BENEFITS AND METHODS OF USE L'OREAL (FR) 2023-07-05 EP disclosed
CN-116322616-A Hair lightening compositions providing damage protection and sensory benefits and methods of use 欧莱雅 2023-06-23 CN disclosed
US-11559474-B2 Hair lightening compositions and methods of use L'OREAL (FR) 2023-01-24 US disclosed
WO-2022047081-A1 HAIR LIGHTENING COMPOSITIONS PROVIDING DAMAGE PROTECTION AND SENSORIAL BENEFITS AND METHODS OF USE HENRY DEREK (US) 2022-03-03 WO disclosed
CN-108546223-B Process for the manufacture of nitriles and their corresponding amines 中国石化扬子石油化工有限公司 2022-02-11 CN disclosed
CN-108164381-B Process for the manufacture of nitriles and their corresponding amines 中国石化扬子石油化工有限公司 2022-02-11 CN disclosed
CN-105016939-A Preparation methods of nitrile and corresponding amine SINOPEC YANGZI PETROCHEMICAL 2015-11-04 CN disclosed
CN-105001032-A Process for the manufacture of nitriles and their corresponding amines SINOPEC YANGZI PETROCHEMICAL 2015-10-28 CN disclosed
US-8968711-B2 Cosmetic or dermatological composition comprising a polymer bearing junction groups, and cosmetic treatment process L'OREAL (FR) 2015-03-03 US disclosed
US-20100272660-A1 COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT L'OREAL (FR) 2010-10-28 US disclosed
US-20100239509-A1 COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS L'OREAL (FR) 2010-09-23 US disclosed
US-20090028807-A1 COMPOSITION COMPRISING A POLYCONDENSATE, METHOD OF TREATMENT, POLYCONDENSATE, AND METHOD OF PREPARATION L'OREAL (FR) 2009-01-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100239509-A1 COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS CUTA, SUCLG1, KRT18 KDM4E 2504/4885LMNA 1561/4885HTT 2106/4885
US-20090028807-A1 COMPOSITION COMPRISING A POLYCONDENSATE, METHOD OF TREATMENT, POLYCONDENSATE, AND METHOD OF PREPARATION CUTA, SYMPK, TPRKB KDM4E 1615/4885LMNA 72/4885HTT 443/4885
US-20100272660-A1 COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT ACMSD, CUTA, PCCA KDM4E 1109/4885LMNA 833/4885HTT 488/4885
US-11559474-B2 Hair lightening compositions and methods of use TYR, ALAD, CYBA KDM4E 2585/4885LMNA 966/4885HTT 478/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.