Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 6/20 | 0.44 |
| ▸ | ALPL | P05186 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28053258 | 0.81 | PKM (0.46) | CA2PTGS1PTGS2CA1CA9 | |
| SCHEMBL28053374 | 0.78 | LRRK2 (0.44) | CA2PTGS1PTGS2CA1CA9 | |
| SCHEMBL16235371 | 0.71 | S100A9 (0.58) | ALPLCYP2C9CYP2C19 | |
| SCHEMBL28053242 | 0.70 | APLNR (0.43) | CA2PTGS1PTGS2CA1CA9 | |
| SCHEMBL28053327 | 0.70 | APLNR (0.45) | CA2PTGS1PTGS2CA1CA9 | |
| SCHEMBL28826183 | 0.70 | APLNR (0.40) | CA2PTGS1PTGS2CA1CA9 | |
| SCHEMBL1081818 | 0.69 | RORC (0.49) | RORCSLC6A4SLC6A3CA2PTGS1 | |
| SCHEMBL28053322 | 0.69 | APLNR (0.51) | CA2PTGS1PTGS2CA1CA9 | |
| SCHEMBL28053239 | 0.68 | APLNR (0.38) | RORCCA2PTGS1PTGS2CA1 | |
| SCHEMBL28826194 | 0.68 | SOS1 (0.39) | CA2CA1CA9CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105377837-A | N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors | ACTIVE BIOTECH AB | 2016-03-02 | — | — | CN | claimed |
| CN-105377837-A | N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors | ACTIVE BIOTECH AB | 2016-03-02 | — | — | CN | disclosed |