Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 13/20 | 0.41 |
| ▸ | CA2 | P00918 | 13/20 | 0.41 |
| ▸ | CA9 | Q16790 | 12/20 | 0.41 |
| ▸ | VRK2 | Q86Y07 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 6/20 | 0.38 |
| ▸ | CA7 | P43166 | 3/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.38 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | CA6 | P23280 | 2/20 | 0.38 |
| ▸ | CA5A | P35218 | 2/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28053322 | 0.89 | APLNR (0.51) | APLNRCA1CA2CA9VRK2 | |
| SCHEMBL28053258 | 0.79 | PKM (0.46) | APLNRCA1CA2CA9VRK2 | |
| SCHEMBL28053347 | 0.76 | CA1 (0.44) | APLNRCA1CA2CA9VRK2 | |
| SCHEMBL28053242 | 0.76 | APLNR (0.43) | APLNRCA1CA2CA9VRK2 | |
| SCHEMBL28053374 | 0.76 | LRRK2 (0.44) | APLNRCA1CA2CA9PTGS1 | |
| SCHEMBL28826186 | 0.73 | VRK2 (0.40) | APLNRCA1CA2CA9VRK2 | |
| SCHEMBL28826183 | 0.73 | APLNR (0.40) | APLNRCA1CA2CA9VRK2 | |
| SCHEMBL28053239 | 0.71 | APLNR (0.38) | APLNRCA1CA2CA9PTGS1 | |
| SCHEMBL28053238 | 0.71 | IKBKB (0.39) | CA1CA2CA9VRK2PTGS1 | |
| SCHEMBL28053244 | 0.70 | RORC (0.44) | CA1CA2CA9PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105377837-A | N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors | ACTIVE BIOTECH AB | 2016-03-02 | — | — | CN | claimed |
| CN-105377837-A | N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors | ACTIVE BIOTECH AB | 2016-03-02 | — | — | CN | disclosed |