Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 5/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | CA9 | Q16790 | 4/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | APLNR | P35414 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28053258 | 0.87 | PKM (0.46) | CA2PTGS1PTGS2CA1CA9 | |
| SCHEMBL28053242 | 0.81 | APLNR (0.43) | CA2PTGS1PTGS2CA1CA9 | |
| SCHEMBL28053244 | 0.78 | RORC (0.44) | CA2PTGS1PTGS2CA1CA9 | |
| SCHEMBL28053327 | 0.76 | APLNR (0.45) | CA2PTGS1PTGS2CA1CA9 | |
| SCHEMBL28826183 | 0.75 | APLNR (0.40) | CA2PTGS1PTGS2CA1CA9 | |
| SCHEMBL10692912 | 0.75 | CA1 (0.56) | LRRK2CA2CA1CA9CA12 | |
| SCHEMBL28053322 | 0.74 | APLNR (0.51) | CA2PTGS1PTGS2PIK3CDPIK3CG | |
| SCHEMBL28053239 | 0.74 | APLNR (0.38) | CA2PTGS1PTGS2CA1CA9 | |
| SCHEMBL28826194 | 0.71 | SOS1 (0.39) | CA2CA1CA9CA12APLNR | |
| SCHEMBL6063752 | 0.70 | CA2 (0.62) | CA2PTGS1PTGS2CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105377837-A | N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors | ACTIVE BIOTECH AB | 2016-03-02 | — | — | CN | claimed |
| CN-105377837-A | N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors | ACTIVE BIOTECH AB | 2016-03-02 | — | — | CN | disclosed |