Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.33 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HCN1 | O60741 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28061589 | 0.90 | SLC6A3 (0.35) | SLC6A2SLC6A4SLC6A3DRD2LMNA | |
| SCHEMBL28061570 | 0.86 | EPHX2 (0.33) | ABL1 | |
| SCHEMBL28061544 | 0.78 | LMNA (0.39) | LMNA | |
| SCHEMBL28061552 | 0.76 | LMNA (0.31) | SLC6A2SLC6A4SLC6A3LMNA | |
| SCHEMBL28061564 | 0.72 | LIPE (0.35) | MEN1KMT2A | |
| SCHEMBL27651774 | 0.70 | DRD2 (0.43) | ALDH1A1MEN1KMT2AATMSLC6A3 | |
| SCHEMBL3542512 | 0.68 | EPHX2 (0.32) | — | |
| SCHEMBL28001641 | 0.67 | SLC6A4 (0.41) | SLC6A2SLC6A4SLC6A3LMNA | |
| SCHEMBL16951433 | 0.66 | CTSS (0.34) | SLC6A2SLC6A3DRD2 | |
| SCHEMBL222030 | 0.66 | MEN1 (0.49) | ALDH1A1MEN1KMT2ADRD2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105693645-A | FUSED HETEROCYCLIC COMPOUNDS AS SODIUM CHANNEL MODULATORS | 吉利德科学公司 | 2016-06-22 | — | — | CN | disclosed |
| CN-103649056-B | Fused heterocyclic compounds as modulators of ion channels | GILEAD SCIENCES, INC. (US) | 2016-04-27 | — | — | CN | disclosed |