Hydrogen Sulfide

Hydrogen Sulfide

SCHEMBL28065679

O=C1c2ccccc2C(=O)c2c1cccc2[N+](=O)[O-].[Na+].[SH-]

nearest known ligand 0.74

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Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrogen Sulfide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 known ✓ P00918 2/20 0.50
CA1 known ✓ P00915 1/20 0.50
ADORA2A known ✓ P29274 1/20 0.47
S100A4 P26447 2/20 0.74
PTPRC P08575 1/20 0.74
MAPT P10636 2/20 0.58
POLB P06746 1/20 0.58
APEX1 P27695 1/20 0.58
CASP6 P55212 1/20 0.58
ALDH1A1 P00352 3/20 0.56
CYP3A4 P08684 2/20 0.56
TP53 P04637 1/20 0.56
CYP1A2 P05177 1/20 0.56
CYP2D6 P10635 1/20 0.56
CYP2C9 P11712 1/20 0.56
MAPK1 P28482 1/20 0.56
CYP2C19 P33261 1/20 0.56
STAT6 P42226 1/20 0.56
HIF1A Q16665 1/20 0.56
PHLPP2 Q6ZVD8 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Anthraquinone SCHEMBL27736010 0.96 S100A4 (0.79) S100A4PTPRCMAPTPOLBAPEX1
SCHEMBL156735 0.96 S100A4 (0.79) S100A4PTPRCMAPTPOLBAPEX1
SCHEMBL27694074 0.95 S100A4 (0.77) S100A4PTPRCMAPTPOLBAPEX1
Ammonia Solution, Strong SCHEMBL27539963 0.95 S100A4 (0.77) S100A4PTPRCMAPTPOLBAPEX1
Water SCHEMBL11135902 0.95 S100A4 (0.77) S100A4PTPRCMAPTPOLBAPEX1
SCHEMBL27694196 0.93 S100A4 (0.74) S100A4PTPRCMAPTPOLBAPEX1
Anthraquinone SCHEMBL27518707 0.93 S100A4 (0.79) S100A4PTPRCMAPTPOLBAPEX1
SCHEMBL11317413 0.91 S100A4 (0.78) S100A4PTPRCMAPTPOLBAPEX1
SCHEMBL2347136 0.91 S100A4 (0.84) S100A4PTPRCMAPTPOLBAPEX1
Bicarbonate SCHEMBL9620804 0.90 S100A4 (0.70) S100A4PTPRCMAPTPOLBAPEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103497116-B The synthetic method of 1-aminoanthraquinone JIANGSU YABANG DYESTUFFS CO., LTD. (CN) 2016-04-20 CN disclosed