Fumaric Acid

Fumaric Acid

SCHEMBL2808165

CC(O)CO.CCCC[Sn+](CCCC)CCCC.CCCC[Sn+](CCCC)CCCC.O=C([O-])/C=C\C(=O)[O-]

nearest known ligand 0.35

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol

The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.35
TDP1 Q9NUW8 1/20 0.34
NFKB1 P19838 1/20 0.32
MAPT P10636 1/20 0.31
GPR84 Q9NQS5 1/20 0.31
CA2 P00918 2/20 0.31
CES2 O00748 1/20 0.30
CES1 P23141 1/20 0.30
ACHE P22303 1/20 0.30
BACE1 P56817 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fumaric Acid SCHEMBL8327122 0.87 CA1 (0.39) CA1CES2CES1
Fumaric Acid SCHEMBL8846375 0.87 CA1 (0.39) CA1CES2CES1
Fumaric Acid SCHEMBL2811329 0.87 CA1 (0.39) CA1CES2CES1
Fumaric Acid SCHEMBL8397710 0.80 CES2 (0.43) CA2CES2CES1
Fumaric Acid SCHEMBL11053356 0.80 CA1 (0.37) CA1CES2CES1
Fumaric Acid SCHEMBL11053404 0.80 CA1 (0.37) CA1CES2CES1
Fumaric Acid SCHEMBL8401314 0.80 CES2 (0.43) CA2CES2CES1
Fumaric Acid SCHEMBL8914966 0.79 CA1 (0.33) CA1CES2CES1
Crotonic Acid SCHEMBL10669353 0.78 CA1 (0.35) CA1CA2CES2CES1
Crotonic Acid SCHEMBL10669368 0.78 CA1 (0.35) CA1CA2CES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2207416-B1 ENHANCED RETENTION CAPABILITIES THROUGH METHODS COMPRISING SURFACE TREATMENT OF FUNCTIONAL PARTICULATE CARRIER MATERIALS, AND FUNCTIONAL PARTICULATE CARRIER MATERIALS MADE THEREFROM IMERYS FILTRATION MINERALS INC (US) 2018-11-07 EP disclosed
US-20100239679-A1 ENHANCED RETENTION CAPABILITIES THROUGH METHODS COMPRISING SURFACE TREATMENT OF FUNCTIONAL PARTICULATE CARRIER MATERIALS, AND FUNCTIONAL PARTICULATE CARRIER MATERIALS MADE THEREFROM WORLD MINERALS, INC. (US) 2010-09-23 US disclosed
EP-2207416-A1 ENHANCED RETENTION CAPABILITIES THROUGH METHODS COMPRISING SURFACE TREATMENT OF FUNCTIONAL PARTICULATE CARRIER MATERIALS, AND FUNCTIONAL PARTICULATE CARRIER MATERIALS MADE THEREFROM World Minerals, Inc. (US) 2010-07-21 EP disclosed
WO-2009045941-A1 ENHANCED RETENTION CAPABILITIES THROUGH METHODS COMPRISING SURFACE TREATMENT OF FUNCTIONAL PARTICULATE CARRIER MATERIALS, AND FUNCTIONAL PARTICULATE CARRIER MATERIALS MADE THEREFROM WORLD MINERALS, INC. (US) 2009-04-09 WO disclosed
US-4284444-A APPLYING BACTERICIDE, FUNGICIDE TO SUBSTRATE ARTICLE HERCULITE PROTECTIVE FABRICS CORPORATION (US) 1981-08-18 US disclosed
US-4204018-A ANTISTATIC AGENT CAPABLE OF MIGRATING THROUGHOUT SUBSTRATE HERCULITE PRODUCTS, INC. 1980-05-20 US disclosed