Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CES1 | P23141 | 6/20 | 0.39 |
| ▸ | CES2 | O00748 | 5/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.35 |
| ▸ | FABP3 | P05413 | 5/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8327122 | 1.00 | CA1 (0.39) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL2811329 | 1.00 | CA1 (0.39) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL11053356 | 0.91 | CA1 (0.37) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL8397710 | 0.91 | CES2 (0.43) | CES1CES2FABP3 | |
| Fumaric Acid SCHEMBL8401314 | 0.91 | CES2 (0.43) | CES1CES2FABP3 | |
| Fumaric Acid SCHEMBL11053404 | 0.91 | CA1 (0.37) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL8914966 | 0.90 | CA1 (0.33) | CA1CES1CES2ATMBBOX1 | |
| Crotonic Acid SCHEMBL10669368 | 0.90 | CA1 (0.35) | CA1CES1CES2ATMBBOX1 | |
| Crotonic Acid SCHEMBL10669353 | 0.90 | CA1 (0.35) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL2808165 | 0.87 | CA1 (0.35) | CA1CES1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106279255-B | Bis (tributyltin) fumarate complex and preparation method and application thereof | 衡阳师范学院 | 2019-12-10 | — | — | CN | claimed |
| US-4270953-A | STORAGE STABILITY | KANSAI PAINT CO., LTD. (JP) | 1981-06-02 | — | — | US | claimed |
| JP-63048202-A | — | — | None | — | — | JP | disclosed |
| CN-109666121-B | Hybrid dynamic cross-linked polymer and application thereof | 厦门逍扬运动科技有限公司 | 2023-09-22 | — | — | CN | disclosed |
| CN-108342049-B | Physical split-phase dynamic polymer and application thereof | 厦门天策材料科技有限公司 | 2023-08-22 | — | — | CN | disclosed |
| CN-109666160-B | Dynamic polymer with hybrid cross-linked network | 厦门天策材料科技有限公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-109206570-B | Flexible physical split-phase supermolecular dynamic polymer and application thereof | 厦门天策材料科技有限公司 | 2023-04-25 | — | — | CN | disclosed |
| CN-109666158-B | Hybrid dynamic polymer and application thereof | 厦门逍扬运动科技有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-111892701-B | Biodegradable copolyester and preparation method thereof | 江苏睿安应用生物技术股份有限公司 | 2022-11-18 | — | — | CN | disclosed |
| CN-111848935-B | Amide group-containing biodegradable copolyester and preparation method thereof | 江苏睿安应用生物技术股份有限公司 | 2022-11-15 | — | — | CN | disclosed |
| CN-114539694-A | Foam type water-soluble packaging film and preparation method thereof | 广东宝德利新材料科技股份有限公司 | 2022-05-27 | — | — | CN | disclosed |
| WO-1991001862-A1 | ANTI-FUNGAL COMPOSITION CONTAINING AN ALKYL SULFOSUCCINATE SALT AND AN OIL COMPONENT | SAFER, INC. (US) | 1991-02-21 | — | — | WO | disclosed |
| US-4820748-A | SOLUTIONS OF FILM FORMING POLYMER CROSSLINKED ACRYLIC RESINS HAVING METAL ESTER BONDS | NIPPON PAINT CO., LTD. (JP) | 1989-04-11 | — | — | US | disclosed |
| US-4769398-A | Antifouling coating composition having improved polishing property | NIPPON PAINT CO., LTD. (JP) | 1988-09-06 | — | — | US | disclosed |
| EP-0260958-A2 | An antifouling coating composition | Nippon Paint Co., Ltd. (JP) | 1988-03-23 | — | — | EP | disclosed |
| JP-S6348202-A | MICROBICIDAL COMPOSITION | SANKYO CO LTD | 1988-02-29 | — | — | JP | disclosed |
| EP-0200433-A2 | Antifouling coating composition | Nippon Paint Co., Ltd. (JP) | 1986-11-05 | — | — | EP | disclosed |
| US-4439555-A | DITHIOCARBAMATES OR THIURAM SULFIDES, TIN COMPOUND | NIPPON OIL AND FATS CO., LTD. (JP) | 1984-03-27 | — | — | US | disclosed |
| US-4270953-A | STORAGE STABILITY | KANSAI PAINT CO., LTD. (JP) | 1981-06-02 | — | — | US | disclosed |
| JP-S06348202-A | — | — | 0001-01-01 | — | — | JP | disclosed |