Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CES1 | P23141 | 6/20 | 0.39 |
| ▸ | CES2 | O00748 | 5/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.35 |
| ▸ | FABP3 | P05413 | 5/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8327122 | 1.00 | CA1 (0.39) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL8846375 | 1.00 | CA1 (0.39) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL11053356 | 0.91 | CA1 (0.37) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL8397710 | 0.91 | CES2 (0.43) | CES1CES2FABP3 | |
| Fumaric Acid SCHEMBL8401314 | 0.91 | CES2 (0.43) | CES1CES2FABP3 | |
| Fumaric Acid SCHEMBL11053404 | 0.91 | CA1 (0.37) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL8914966 | 0.90 | CA1 (0.33) | CA1CES1CES2ATMBBOX1 | |
| Crotonic Acid SCHEMBL10669368 | 0.90 | CA1 (0.35) | CA1CES1CES2ATMBBOX1 | |
| Crotonic Acid SCHEMBL10669353 | 0.90 | CA1 (0.35) | CA1CES1CES2ATMBBOX1 | |
| Fumaric Acid SCHEMBL2808165 | 0.87 | CA1 (0.35) | CA1CES1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 153 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391662-B1 | PREPARATION OF A PYRITHIONE SALT DISPERSION USABLE IN URETHANE APPLICATIONS | ARCH CHEM INC (US) | 2016-08-10 | — | — | EP | claimed |
| US-8286667-B2 | Prevention of bacterial adhesion irrigation conduits | A.I. INNOVATIONS, N.V. (US) | 2012-10-16 | — | — | US | claimed |
| EP-2391662-A1 | PREPARATION OF A PYRITHIONE SALT DISPERSION USABLE IN URETHANE APPLICATIONS | Arch Chemicals, Inc. (US) | 2011-12-07 | — | — | EP | claimed |
| US-20100240800-A1 | BIOCIDAL ELASTOMERIC COMPOSITIONS AND METHODS OF MAKING THE SAME | DASH MULTI-CORP (US) | 2010-09-23 | — | — | US | claimed |
| WO-2010088157-A1 | PREPARATION OF A PYRITHIONE SALT DISPERSION USABLE IN URETHANE APPLICATIONS | ARCH CHEMICALS, INC. (US) | 2010-08-05 | — | — | WO | claimed |
| US-20100196506-A1 | Preparation of a pyrithione salt dispersion usable in urethane applications | ARCH CHEMICALS, INC. | 2010-08-05 | — | — | US | claimed |
| US-20090250137-A1 | Low friction lining for drip irrigation conduits | CAST ENVIRONMENTAL SOLUTIONS, LLC | 2009-10-08 | — | — | US | claimed |
| US-20070209144-A1 | VACUUM CLEANER WITH IMPROVED HYGENIC PERFORMANCE | BISSELL HOMECARE, INC. (US) | 2007-09-13 | — | — | US | claimed |
| US-20060067989-A1 | Degradable Animal Chewing Article Possessing Enhanced Safety, Durability, and Mouth-Feel | DENESUK MATTHEW | 2006-03-30 | — | — | US | claimed |
| US-6972133-B1 | Degradable animal chewing article possessing enhanced safety, durability and mouth-feel | SEEFAR TECHNOLOGIES, INC. (US) | 2005-12-06 | — | — | US | claimed |
| US-6576246-B1 | Degradable animal chewing article possessing enhanced safety, durability and mouth-feel | SEEFAR TECHNOLOGIES, INC. | 2003-06-10 | — | — | US | claimed |
| US-6178922-B1 | Mastication article possessing microbe-inhibiting properties | SEEFAR TECHNOLOGIES, INC. | 2001-01-30 | — | — | US | claimed |
| EP-0685460-B1 | PROCESS FOR PRODUCING HIGHER CYANOACETIC ESTER | MITSUBISHI RAYON CO (JP) | 1999-06-09 | — | — | EP | claimed |
| US-5902871-A | USING A TRIORGANOTIN CATALYST FOR REACTING AT A TEMPERATURE BELOW 150 DEGREES C. A BLOCKED ISOCYANATE OR ISOCYANATE AND AN EPOXY; ELECTROLYTICALLY DEPOSITED COATINGS; NONTOXIC; KINETICS | ELF ATOCHEM NORTH AMERICA, INC. (US) | 1999-05-11 | — | — | US | claimed |
| US-5880178-A | CONDUCTIVE COATINGS TRIORGANOTIN CATALYST | ELF ATOCHEM NORTH AMERICA, INC. (US) | 1999-03-09 | — | — | US | claimed |
| US-5698730-A | TRANSESTERIFICATION REACTION OF CYANOACETIC ACID ESTER WITH ALCOHOL IN THE PRESENCE OF ORGANOTIN CATALYST | NITTO CHEMICAL INDUSTRY CO., LTD. (JP) | 1997-12-16 | — | — | US | claimed |
| EP-0685460-A1 | PROCESS FOR PRODUCING HIGHER CYANOACETIC ESTER | NITTO CHEMICAL INDUSTRY CO., LTD. (JP) | 1995-12-06 | — | — | EP | claimed |
| US-4560716-A | Rust preventing epoxy resin compositions | KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) | 1985-12-24 | — | — | US | claimed |
| US-4552907-A | LANOLIN, CORROSION RESISTANCE | KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) | 1985-11-12 | — | — | US | claimed |
| US-4270953-A | STORAGE STABILITY | KANSAI PAINT CO., LTD. (JP) | 1981-06-02 | — | — | US | claimed |