Fumaric Acid

Fumaric Acid

SCHEMBL8327122

CCCC[Sn+](CCCC)CCCC.CCCC[Sn+](CCCC)CCCC.O=C([O-])C=CC(=O)[O-]

nearest known ligand 0.46

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Known targets — ChEMBL curated mechanism

ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol

The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.39
CES1 P23141 6/20 0.39
CES2 O00748 5/20 0.39
ATM Q13315 1/20 0.35
BBOX1 O75936 1/20 0.35
FABP3 P05413 5/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fumaric Acid SCHEMBL8846375 1.00 CA1 (0.39) CA1CES1CES2ATMBBOX1
Fumaric Acid SCHEMBL2811329 1.00 CA1 (0.39) CA1CES1CES2ATMBBOX1
Fumaric Acid SCHEMBL11053356 0.91 CA1 (0.37) CA1CES1CES2ATMBBOX1
Fumaric Acid SCHEMBL8397710 0.91 CES2 (0.43) CES1CES2FABP3
Fumaric Acid SCHEMBL8401314 0.91 CES2 (0.43) CES1CES2FABP3
Fumaric Acid SCHEMBL11053404 0.91 CA1 (0.37) CA1CES1CES2ATMBBOX1
Fumaric Acid SCHEMBL8914966 0.90 CA1 (0.33) CA1CES1CES2ATMBBOX1
Crotonic Acid SCHEMBL10669368 0.90 CA1 (0.35) CA1CES1CES2ATMBBOX1
Crotonic Acid SCHEMBL10669353 0.90 CA1 (0.35) CA1CES1CES2ATMBBOX1
Fumaric Acid SCHEMBL2808165 0.87 CA1 (0.35) CA1CES1CES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106279255-B Bis (tributyltin) fumarate complex and preparation method and application thereof 衡阳师范学院 2019-12-10 CN claimed
EP-0685460-B1 PROCESS FOR PRODUCING HIGHER CYANOACETIC ESTER MITSUBISHI RAYON CO (JP) 1999-06-09 EP claimed
US-5902871-A USING A TRIORGANOTIN CATALYST FOR REACTING AT A TEMPERATURE BELOW 150 DEGREES C. A BLOCKED ISOCYANATE OR ISOCYANATE AND AN EPOXY; ELECTROLYTICALLY DEPOSITED COATINGS; NONTOXIC; KINETICS ELF ATOCHEM NORTH AMERICA, INC. (US) 1999-05-11 US claimed
US-5880178-A CONDUCTIVE COATINGS TRIORGANOTIN CATALYST ELF ATOCHEM NORTH AMERICA, INC. (US) 1999-03-09 US claimed
US-5698730-A TRANSESTERIFICATION REACTION OF CYANOACETIC ACID ESTER WITH ALCOHOL IN THE PRESENCE OF ORGANOTIN CATALYST NITTO CHEMICAL INDUSTRY CO., LTD. (JP) 1997-12-16 US claimed
EP-0685460-A1 PROCESS FOR PRODUCING HIGHER CYANOACETIC ESTER NITTO CHEMICAL INDUSTRY CO., LTD. (JP) 1995-12-06 EP claimed
JP-61247779-A None JP disclosed
CN-110891993-B Low temperature curing 1K basecoat and method for coating a substrate with a 1K basecoat 巴斯夫涂料有限公司 2022-11-22 CN disclosed
CN-110945085-B Low temperature cured coatings formed by polarity-promoted catalyst migration between layers in a two-layer cure mechanism 巴斯夫涂料有限公司 2022-07-12 CN disclosed
CN-109476811-B One-part low temperature cure coating formed via a dual layer cure mechanism 巴斯夫涂料有限公司 2022-02-11 CN disclosed
CN-109476933-B Low temperature cured coatings via a dual layer cure mechanism of a pigmented water-based base layer and a solvent-based top layer 巴斯夫涂料有限公司 2021-10-12 CN disclosed
CN-110945085-A Low temperature cured coatings formed by polarity-promoted catalyst migration between layers in a dual-layer cure mechanism 巴斯夫涂料有限公司 2020-03-31 CN disclosed
CN-110891993-A Low temperature curing 1K basecoat and method of coating a substrate with a 1K basecoat 巴斯夫涂料有限公司 2020-03-17 CN disclosed
JP-S61247779-A NOVEL COVERING MATERIAL FOR PREVENTING DEPOSITION OF ICE AND SNOW SHINTO PAINT CO LTD 1986-11-05 JP disclosed
EP-0091039-B1 ANTI-FOULING AGENT Nitto Kasei Co., Ltd. (JP) 1986-10-01 EP disclosed
US-4439555-A DITHIOCARBAMATES OR THIURAM SULFIDES, TIN COMPOUND NIPPON OIL AND FATS CO., LTD. (JP) 1984-03-27 US disclosed
EP-0091039-A2 Anti-fouling agent Nitto Kasei Co., Ltd. (JP) 1983-10-12 EP disclosed
US-4404328-A CHLORINATED CONJUGATED DIENE, ORGANOTIN COMPOUND, HYDROPHILIC MONOMER GRAFT POLYMER INSTITUT FRANCAIS DU PETROLE (FR) 1983-09-13 US disclosed
US-4281175-A TRANSESTERIFICATION WITH ALKYLTIN CATALYSTS NITTO CHEMICAL INDUSTRY CO., LTD. (JP) 1981-07-28 US disclosed
US-4262097-A CONTAINING TIN AND CHLORINE INSTITUT FRANCAIS DU PETROLE (FR) 1981-04-14 US disclosed