Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Clobazam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 8/20 | 0.46 |
| ▸ | GABRA5 known ✓ | P31644 | 8/20 | 0.46 |
| ▸ | GABRA3 known ✓ | P34903 | 8/20 | 0.46 |
| ▸ | GABRA2 known ✓ | P47869 | 8/20 | 0.46 |
| ▸ | GABRB2 known ✓ | P47870 | 7/20 | 0.46 |
| ▸ | GABRG2 known ✓ | P18507 | 5/20 | 0.42 |
| ▸ | GABRB3 known ✓ | P28472 | 5/20 | 0.42 |
| ▸ | GABRP known ✓ | O00591 | 3/20 | 0.41 |
| ▸ | GABRD known ✓ | O14764 | 3/20 | 0.41 |
| ▸ | GABRB1 known ✓ | P18505 | 3/20 | 0.41 |
| ▸ | GABRA4 known ✓ | P48169 | 3/20 | 0.41 |
| ▸ | GABRE known ✓ | P78334 | 3/20 | 0.41 |
| ▸ | GABRA6 known ✓ | Q16445 | 3/20 | 0.41 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 3/20 | 0.41 |
| ▸ | GABRG3 known ✓ | Q99928 | 3/20 | 0.41 |
| ▸ | GABRQ known ✓ | Q9UN88 | 3/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diazepam SCHEMBL8329713 | 0.85 | ADRA1A (0.64) | ADRA1AOPRK1PDE4DGABRA1GABRA5 | |
| Diazepam SCHEMBL10351230 | 0.79 | ADRA1A (0.54) | ADRA1AOPRK1PDE4DGABRA1GABRA5 | |
| Bromazepam SCHEMBL43933 | 0.78 | ADRA1A (1.00) | ADRA1AOPRK1PDE4DGABRA1GABRA5 | |
| Bromazepam SCHEMBL29366892 | 0.78 | ADRA1A (1.00) | ADRA1AOPRK1PDE4DGABRA1GABRA5 | |
| Bromazepam SCHEMBL29382152 | 0.78 | ADRA1A (1.00) | ADRA1AOPRK1PDE4DGABRA1GABRA5 | |
| Bromazepam SCHEMBL29521776 | 0.78 | ADRA1A (1.00) | ADRA1AOPRK1PDE4DGABRA1GABRA5 | |
| Clonazepam SCHEMBL3065470 | 0.77 | GABRA1 (0.64) | ADRA1AOPRK1PDE4DGABRA1GABRA5 | |
| Lorazepam SCHEMBL4978513 | 0.76 | ADRA1A (0.51) | ADRA1AOPRK1PDE4DGABRA1GABRA5 | |
| Alprazolam SCHEMBL3664716 | 0.76 | GABRA1 (0.66) | ADRA1AOPRK1PDE4DGABRA1GABRA5 | |
| SCHEMBL7377690 | 0.76 | ADRA1A (0.74) | ADRA1AOPRK1PDE4DGABRA1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |