Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Diazepam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 4/20 | 0.51 |
| ▸ | GABRA5 known ✓ | P31644 | 4/20 | 0.51 |
| ▸ | GABRA3 known ✓ | P34903 | 4/20 | 0.51 |
| ▸ | GABRA2 known ✓ | P47869 | 4/20 | 0.51 |
| ▸ | GABRB2 known ✓ | P47870 | 4/20 | 0.51 |
| ▸ | GABRG2 known ✓ | P18507 | 2/20 | 0.51 |
| ▸ | GABRB3 known ✓ | P28472 | 2/20 | 0.51 |
| ▸ | GABRP known ✓ | O00591 | 1/20 | 0.51 |
| ▸ | GABRD known ✓ | O14764 | 1/20 | 0.51 |
| ▸ | GABRB1 known ✓ | P18505 | 1/20 | 0.51 |
| ▸ | GABRA4 known ✓ | P48169 | 1/20 | 0.51 |
| ▸ | GABRE known ✓ | P78334 | 1/20 | 0.51 |
| ▸ | GABRA6 known ✓ | Q16445 | 1/20 | 0.51 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 1/20 | 0.51 |
| ▸ | GABRG3 known ✓ | Q99928 | 1/20 | 0.51 |
| ▸ | GABRQ known ✓ | Q9UN88 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.51 |
| ▸ | ALB | P02768 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lorazepam SCHEMBL4978513 | 0.95 | ADRA1A (0.51) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| Diazepam SCHEMBL8329713 | 0.92 | ADRA1A (0.64) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| Diazepam SCHEMBL10948878 | 0.86 | GABRA1 (0.69) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Lorazepam SCHEMBL4976540 | 0.81 | LMNA (0.65) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Diazepam SCHEMBL6823824 | 0.81 | GABRA1 (0.79) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Diazepam SCHEMBL8931438 | 0.81 | GABRA1 (0.79) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Oxazepam SCHEMBL6680438 | 0.80 | LMNA (0.81) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Alprazolam SCHEMBL3664716 | 0.79 | GABRA1 (0.66) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| Clobazam SCHEMBL28086348 | 0.79 | ADRA1A (0.61) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| Temazepam SCHEMBL7036032 | 0.76 | OPRK1 (0.82) | GABRA1GABRA5GABRA3GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0167825-A2 | Lipid nano pellets as drug carriers for oral administration | Dr. Rentschler Arzneimittel GmbH & Co. (DE) | 1986-01-15 | — | — | EP | claimed |
| EP-0167825-B1 | LIPID NANO PELLETS AS DRUG CARRIERS FOR ORAL ADMINISTRATION | Dr. Rentschler Arzneimittel GmbH & Co. (DE) | 1990-08-08 | — | — | EP | disclosed |
| EP-0167825-A2 | Lipid nano pellets as drug carriers for oral administration | Dr. Rentschler Arzneimittel GmbH & Co. (DE) | 1986-01-15 | — | — | EP | disclosed |