SCHEMBL28126011

SCHEMBL28126011

FC(F)(F)c1[c]cccc1-c1cc(Br)ccc1Br

nearest known ligand 0.36

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PTPRC P08575 1/20 0.36
PDK2 Q15119 1/20 0.33
S100A4 P26447 1/20 0.32
CYP1A2 P05177 1/20 0.32
MAPK1 P28482 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11032497 0.83 ALDH1A1 (0.38) PDK2MAPK1
SCHEMBL28126044 0.78 ALDH1A1 (0.34) PTPRCMAPK1
SCHEMBL9770289 0.77 ENPP3 (0.33) PDK2
SCHEMBL28839943 0.75 PDK2 (0.35) PDK2S100A4
SCHEMBL4437742 0.75 PTPRC (0.39) PTPRCS100A4CYP1A2MAPK1
SCHEMBL1068615 0.73 ENPP3 (0.33)
SCHEMBL15637439 0.71 GPR3 (0.33)
SCHEMBL2431241 0.70 HTR1A (0.33) PTPRCPDK2
SCHEMBL6987649 0.70 HSD11B1 (0.41) CYP1A2MAPK1
SCHEMBL28453298 0.70 S100A4 (0.57) PTPRCS100A4CYP1A2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106458955-B Aryl substituted heterocyclyl sulfones 格吕伦塔尔有限公司 2019-07-19 CN disclosed
CN-106458955-A Aryl substituted heterocyclyl sulfones 格吕伦塔尔有限公司 2017-02-22 CN disclosed