Tryptophan

SCHEMBL27746464

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nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	RXFP1	Q9HBX9	1/20	0.42

▸	PTH1R	Q03431	9/20	0.40

▸	GLP1R	P43220	1/20	0.39

▸	GCGR	P47871	1/20	0.39

▸	GIPR	P48546	1/20	0.39

▸	CTSC	P53634	2/20	0.39

▸	TLR2	O60603	3/20	0.38

▸	MEN1	O00255	1/20	0.38

▸	KMT2A	Q03164	1/20	0.38

▸	MAGI3	Q5TCQ9	1/20	0.38

▸	IL23R	Q5VWK5	2/20	0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Tryptophan SCHEMBL28144336	0.94	RXFP1 (0.41)	RXFP1PTH1RGLP1RGCGRGIPR
Dl-Tryptophan SCHEMBL28130698	0.82	KMT2A (0.45)	MEN1KMT2A
Dl-Tryptophan SCHEMBL28079286	0.81	KDM4E (0.43)	PTH1RGLP1RMEN1KMT2AMAGI3
Dl-Tryptophan SCHEMBL29151523	0.81	KDM4E (0.54)	MEN1KMT2A
Tryptophan SCHEMBL27459392	0.80	KEAP1 (0.43)	GLP1R
Dl-Tryptophan SCHEMBL28880639	0.80	KDM4E (0.45)	RXFP1PTH1RMEN1KMT2AIL23R
Dl-Tryptophan SCHEMBL28196606	0.79	MEN1 (0.49)	MEN1KMT2A
Dl-Tryptophan SCHEMBL29025197	0.79	KMT2A (0.54)	MEN1KMT2A
Dl-Tryptophan SCHEMBL28066306	0.79	KDM4E (0.54)	MEN1KMT2A
Tryptophan SCHEMBL23698367	0.79	CTSC (0.51)	CTSCMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-101328207-B	Citrus fruit fly antibacterial peptide, preparation and use thereof	UNIV SOUTH CHINA AGRICULT	2011-05-18	—	—	CN	disclosed
CN-101328207-A	Citrus fruit fly antibacterial peptide, preparation and use thereof	UNIV SOUTH CHINA AGRICULT (CN)	2008-12-24	—	—	CN	disclosed