Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 5/20 | 0.32 |
| ▸ | NOS3 | P29474 | 4/20 | 0.32 |
| ▸ | NOS1 | P29475 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1225131 | 1.00 | ALDH1A1 (0.33) | ALDH1A1TSHRNOS2NOS3NOS1 | |
| SCHEMBL1224900 | 0.79 | — | — | |
| SCHEMBL4379629 | 0.78 | ACHE (0.38) | ALDH1A1 | |
| SCHEMBL16447448 | 0.78 | ACHE (0.38) | ALDH1A1 | |
| SCHEMBL16414300 | 0.76 | LMNA (0.31) | — | |
| SCHEMBL1223821 | 0.76 | ALDH1A1 (0.38) | ALDH1A1TSHRNOS2NOS3NOS1 | |
| SCHEMBL14653011 | 0.76 | ALDH1A1 (0.38) | ALDH1A1TSHRNOS2NOS3NOS1 | |
| SCHEMBL12584883 | 0.76 | ALDH1A1 (0.38) | ALDH1A1TSHRNOS2NOS3NOS1 | |
| SCHEMBL4371664 | 0.75 | NPC1 (0.31) | ALDH1A1 | |
| SCHEMBL15137106 | 0.74 | TAS1R3 (0.38) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190106416-A1 | PROCESS FOR THE PREPARATION OF PROPIONIC ACID DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2019-04-11 | — | — | US | disclosed |
| US-9238667-B2 | Rhodium catalyst and method for producing amine compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-01-19 | — | — | US | disclosed |
| US-9238667-B2 | Rhodium catalyst and method for producing amine compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-01-19 | — | — | US | disclosed |
| EP-2411385-B1 | PROCESS FOR THE PREPARATION OF PROPIONIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2015-08-05 | — | — | EP | disclosed |
| US-20150051416-A1 | RHODIUM CATALYST AND METHOD FOR PRODUCING AMINE COMPOUND | SPERA PHARMA, INC. (JP) | 2015-02-19 | — | — | US | disclosed |
| US-20150051416-A1 | RHODIUM CATALYST AND METHOD FOR PRODUCING AMINE COMPOUND | SPERA PHARMA, INC. (JP) | 2015-02-19 | — | — | US | disclosed |
| US-20150025249-A1 | PROCESS FOR THE PREPARATION OF PROPIONIC ACID DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-01-22 | — | — | US | disclosed |
| US-20130184468-A1 | PROCESS FOR THE PREPARATION OF PROPIONIC ACID DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2013-07-18 | — | — | US | disclosed |
| US-8450496-B2 | Process for the preparation of propionic acid derivatives | HOFFMAN-LA ROCHE INC. (US) | 2013-05-28 | — | — | US | disclosed |
| EP-2585452-A1 | PROCESS FOR THE PREPARATION OF PROPIONIC ACID DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-01 | — | — | EP | disclosed |
| US-20100249428-A1 | PROCESS FOR THE PREPARATION OF PROPIONIC ACID DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150025249-A1 | PROCESS FOR THE PREPARATION OF PROPIONIC ACID DERIVATIVES | PCCA, SLC6A1, SLC6A11 | ALDH1A1 92/4885TSHR 1916/4885NOS2 2878/4885 |
| US-20150051416-A1 | RHODIUM CATALYST AND METHOD FOR PRODUCING AMINE COMPOUND | PRMT7, PRMT5, HNMT | ALDH1A1 2581/4885TSHR 846/4885NOS2 91/4885 |
| US-20130184468-A1 | PROCESS FOR THE PREPARATION OF PROPIONIC ACID DERIVATIVES | PCCA, SLC6A1, SLC6A11 | ALDH1A1 92/4885TSHR 1916/4885NOS2 2878/4885 |
| US-20100249428-A1 | PROCESS FOR THE PREPARATION OF PROPIONIC ACID DERIVATIVES | PCCA, SLC6A1, SLC6A11 | ALDH1A1 92/4885TSHR 1916/4885NOS2 2878/4885 |
| US-20190106416-A1 | PROCESS FOR THE PREPARATION OF PROPIONIC ACID DERIVATIVES | PCCA, SLC6A1, SLC6A11 | ALDH1A1 92/4885TSHR 1916/4885NOS2 2878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.