Sugi Predict

Sugi Predict / Compounds / SCHEMBL2817519

SCHEMBL2817519

SCHEMBL2817519

O=C(O)c1c[nH]c2ccncc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NAMPT P43490 1/20 0.51
▸ F7 P08709 1/20 0.50
▸ F3 P13726 1/20 0.50
▸ HASPIN Q8TF76 1/20 0.48
▸ HTR6 P50406 2/20 0.47
▸ KDM4E B2RXH2 3/20 0.47
▸ KDM4C Q9H3R0 2/20 0.47
▸ MEN1 O00255 1/20 0.47
▸ KDM6B O15054 1/20 0.47
▸ KDM4A O75164 1/20 0.47
▸ ALDH1A1 P00352 1/20 0.47
▸ MAPT P10636 1/20 0.47
▸ THRB P10828 1/20 0.47
▸ KMT2A Q03164 1/20 0.47
▸ KDM4D Q6B0I6 1/20 0.47
▸ TDP1 Q9NUW8 1/20 0.47
▸ L3MBTL1 Q9Y468 1/20 0.47
▸ ROCK1 Q13464 1/20 0.46
▸ CYP3A4 P08684 1/20 0.46
▸ CYP2C19 P33261 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6778035 0.90 KDM4E (0.55) NAMPTF7F3HASPINHTR6
SCHEMBL369404 0.88 CYP2C19 (0.48) NAMPTF7F3HASPINHTR6
SCHEMBL22049722 0.86 ALDH1A1 (0.59) NAMPTHASPINHTR6KDM4EALDH1A1
SCHEMBL12481581 0.86 HASPIN (0.64) NAMPTHASPINHTR6KDM4EROCK1
SCHEMBL30101234 0.85 DYRK1A (0.51) F7F3HASPINKDM4EKDM4C
SCHEMBL2052704 0.85 DYRK1A (0.51) F7F3HASPINKDM4EKDM4C
SCHEMBL30066929 0.84 GPR84 (0.51) NAMPTMEN1ALDH1A1KMT2AROCK1
Potassium Ion SCHEMBL3887398 0.83 NAMPT (0.47) NAMPTHASPINHTR6MEN1ALDH1A1
SCHEMBL3887392 0.83 HTR6 (0.46) NAMPTHASPINHTR6KDM4EMEN1
SCHEMBL3010111 0.82 MAPK1 (0.62) NAMPTHASPINHTR6ROCK1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12577243-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2026-03-17 — — US disclosed
EP-3856178-B1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2026-03-11 — — EP disclosed
CN-113164459-B Monoacylglycerol lipase modulators 詹森药业有限公司 2024-09-03 — — CN disclosed
US-11820766-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 — — US disclosed
US-20230145249-A1 Monoacylglycerol Lipase Modulators JANSSEN PHARMACEUTICA NV (BE) 2023-05-11 — — US disclosed
US-20220332713-A1 Monoacylglycerol Lipase Modulators JANSSEN PHARMACEUTICA NV (BE) 2022-10-20 — — US disclosed
CN-108530444-B Novel NAMPT and IDO dual inhibitor and preparation method and medical application thereof 药康众拓(江苏)医药科技有限公司 2021-08-24 — — CN disclosed
EP-3856178-A1 MONOACYLGLYCEROL LIPASE MODULATORS Janssen Pharmaceutica NV (BE) 2021-08-04 — — EP disclosed
CN-113164459-A Monoacylglycerol lipase modulators 詹森药业有限公司 2021-07-23 — — CN disclosed
CN-112239468-A Metal-free and solvent-free synthesis of fused pyridine heterocycles and biomedical applications thereof 文卡特什·切尔姆 2021-01-19 — — CN disclosed
CN-111518095-A Azaindole derivatives, and preparation method and application thereof 华东师范大学 2020-08-11 — — CN disclosed
US-20200172534-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY NOVARTIS PHARMA AG (CH) 2020-06-04 — — US disclosed
US-20200102303-A1 Monoacylglycerol Lipase Modulators JANSSEN PHARMACEUTICA NV (BE) 2020-04-02 — — US disclosed
WO-2020065613-A1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2020-04-02 — — WO disclosed
US-10005773-B2 1-(4-pyrimidinyl)-1H-pyrrolo[3,2-c]pyridine derivatives as NIK inhibitors JANSSEN PHARMACEUTICA NV (BE) 2018-06-26 — — US disclosed
US-20160257679-A1 NEW 1-(4-PYRIMIDINYL)-1H-PYRROLO[3,2-c]PYRIDINE DERIVATIVES AS NIK INHIBITORS ARGENTA DISCOVERY 2009 LIMITED (GB) 2016-09-08 — — US disclosed
US-20100249123-A1 NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE ADDEX PHARMA SA (CH) 2010-09-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220332713-A1 Monoacylglycerol Lipase Modulators MGLL, LPL, PNLIP NAMPT 3919/4885F7 3961/4885F3 1278/4885
US-10005773-B2 1-(4-pyrimidinyl)-1H-pyrrolo[3,2-c]pyridine derivatives as NIK inhibitors MAP3K14, MAP3K15, MAP3K12 NAMPT 422/4885F7 4729/4885F3 1507/4885
US-12577243-B2 Monoacylglycerol lipase modulators MGLL, LPL, FAAH NAMPT 4738/4885F7 3585/4885F3 2880/4885
US-20200102303-A1 Monoacylglycerol Lipase Modulators MGLL, LPL, PNLIP NAMPT 3919/4885F7 3961/4885F3 1278/4885
US-20100249123-A1 NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE FSHR, GNRHR, SHBG NAMPT 3096/4885F7 468/4885F3 92/4885
US-20230145249-A1 Monoacylglycerol Lipase Modulators MGLL, LPL, PNLIP NAMPT 3919/4885F7 3961/4885F3 1278/4885
US-20200172534-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY STING1, CGAS, IRF3 NAMPT 2899/4885F7 4066/4885F3 4163/4885
US-11820766-B2 Monoacylglycerol lipase modulators MGLL, LPL, PNLIP NAMPT 3919/4885F7 3961/4885F3 1278/4885
US-20160257679-A1 NEW 1-(4-PYRIMIDINYL)-1H-PYRROLO[3,2-c]PYRIDINE DERIVATIVES AS NIK INHIBITORS MAP3K14, MAP3K15, MAP3K12 NAMPT 507/4885F7 4728/4885F3 1610/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.